Elevated Triglyceride-Glucose Index Linked to 32 Percent Higher Overactive Bladder Risk: NHANES Study

China: A recent study analyzing data from the US National Health and Nutrition Examination Survey (NHANES) spanning 2005 to 2018 has uncovered a significant association between the triglyceride-glucose (TyG) index and the prevalence of overactive bladder (OAB).
The findings, published in Frontiers in Endocrinology by Baitong Chen from The First School of Clinical Medicine, Guangdong Medical University, and colleagues, suggest that the TyG index—a marker of insulin resistance—could serve as a useful early indicator of OAB risk, particularly in specific demographic groups.
OAB, characterized by a frequent and urgent need to urinate, is a condition that can significantly impair quality of life. While its association with metabolic factors has been suggested in earlier studies, the potential role of the TyG index in predicting OAB has remained largely unexplored until now.
The study evaluated 14,059 individuals from the NHANES dataset, of whom 3,325 were identified as having OAB. The researchers applied both univariate and multivariate logistic regression models to examine the relationship between the TyG index and OAB risk. Additionally, restricted cubic spline (RCS) curves were used to explore the dose-response relationship.
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