Enzalutamide plus ADT effective in Metastatic Prostate Cancer, Finds study

The following results were observed-

a. Of the overall population with metastases identified at enrollment (n=1,146), the largest patient subgroups were those with bone metastases only (n=513) and those with bone plus lymph node metastases (n=351); there were fewer men with lymph node metastases only (n=154) and men with visceral±bone or lymph node metastases (n=128).

b. Enzalutamide plus ADT reduced the risk of radiographic progression versus placebo plus ADT in men with bone metastases only (HR 0.33) and bone plus lymph node metastases (HR 0.31).

c. Similar improvements in secondary end points were also observed in these subgroups.

Therefore, the investigators concluded that "treatment with enzalutamide plus ADT provides improvements in men with bone and/or lymph node metastases, but may be less effective in men with visceral patterns of spread."

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Armstrong AJ, Shore ND, Szmulewitz RZ, Petrylak DP, Holzbeierlein J, Villers A, Azad A, Alcaraz A, Alekseev B, Iguchi T, Gomez-Veiga F, Rosbrook B, Lee HJ, Haas GP, Stenzl A. Efficacy of Enzalutamide plus Androgen Deprivation Therapy in Metastatic Hormone-Sensitive Prostate Cancer by Pattern of Metastatic Spread: ARCHES Post Hoc Analyses. J Urol. 2020 Dec 28:101097JU0000000000001568.

doi: 10.1097/JU.0000000000001568.