Enzalutamide plus ADT effective in Metastatic Prostate Cancer, Finds study
Researchers from the Duke Cancer Institute Center for Prostate & Urologic Cancers, Durham, North Carolina have recently noted that treatment with enzalutamide plus ADT provides improvements in men with bone and/or lymph node metastases, but may be less effective in men with visceral patterns of spread, according to the study published in the Journal of Urology.
Enzalutamide plus ADT has previously been shown to improve clinical outcomes in men with metastatic hormone sensitive prostate cancer. Hence, Andrew J Armstrong and colleagues conducted this study to assess if and how the pattern of metastatic spread impacts efficacy of enzalutamide plus ADT in men enrolled in ARCHES.
Men with metastatic hormone sensitive prostate cancer were randomized 1:1 to enzalutamide (160 mg/day) plus ADT or placebo plus ADT, stratified by disease volume and prior docetaxel treatment. The primary end point was radiographic progression-free survival. Secondary end points included time to prostate specific antigen progression, initiation of new antineoplastic therapy, first symptomatic skeletal event and castration resistance. Post hoc analyses were performed by pattern of metastatic spread based on study entry imaging.
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