Fosfomycin useful treatment option for uncomplicated cystitis among females
Researchers investigating Local bacterial resistance patterns assessment to focus first-line UTI antibiotics has found that Fosfomycin is a useful treatment option for uncomplicated cystitis among female patients.
The new study has been published in the International Journal of Antimicrobial Agents.
The study was done to report the resistance rate against fosfomycin trometamol among outpatient women with symptoms related to UTI during a 6 years-period in a multicentre cross-sectional study.
Urinary samples were collected from three high volume laboratories from January 2015 to December 2020. The pattern of resistance to fosfomycin was analysed by using the Vitek II automated system.
Results
During the study period 7,289 urinary samples were collected and 8,321 strains were analysed. Escherichia coli was the most common isolated uropathogens (n=6,583, 79.1%). The mean resistance rate against fosfomycin was 9.7% (ranging from 7.1 to 11.3). No statistically significant difference was found between the three laboratories (p=0.53). There was no significant increase in resistance rate during the study period. The mean resistance rate against fosfomycin was higher among ESBL-producing bacteria when compared with no ESBL-producing strains (10.8% vs 7.9%, p<0.001).
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