Glycogen deposition in detrusor wall may not hinder urodynamic parameters in BHP patients

In patients with benign prostate hyperplasia (BPH) facing Bladder Outlet Obstruction (BOO), the increased amount of glycogen deposition in the detrusor muscle did not correlate with any severity of symptoms and duration or urodynamic findings. The findings were published in the World Journal of Urology.

A prospective study was carried forward by Iraklis Mitsogiannis to evaluate if the glycogen deposition within the detrusor muscle of the bladder has any correlation with the urodynamic findings/ symptoms in patients undergoing bladder outlet obstruction due to benign prostate hyperplasia. 

A total of 50 patients with BPH (Study Group) and 20 individuals (Control Group) were analyzed completely. BOO was confirmed with the help of pressure-flow studies. Glycogen deposition within the bladder wall was the main outcome focused. And so, Bladder tissue biopsies were obtained from all the participants. Further histological assessment was performed using Periodate Acid Schiff's (PAS) stain for the analysis of detrusor glycogen content. Score of the obtained glycogen ranged from 0 (no glycogen granules stained) to 3 (glycogen granules within the detrusor adjacent to the urothelium stained).

The findings of the study were:

• Of the 50 patients and 20 controls included, increased glycogen deposition was noticed in 37 (74%) and 2 (10%) patients in the Study and Control Group, respectively.
• Subgroup analysis showed no statistically significant difference between glycogen deposition score and IPSS, maximum detrusor pressure at maximum flow (PdetQmax) and duration of LUTS.
• The history of retention was the only reliable variable that could predict high glycogen deposition in the multivariate logistic regression.

Results of the urodynamic parameters assessed did not bring out any reliable link between the amount of glycogen deposition within the detrusor wall and severity of urodynamic symptoms.

Source:

Mitsogiannis, I., Komninos, C., Karakosta, A., Papatsoris, A., Skolarikos, A., & Tzelves, L. (2022). "Glycogen deposition in the detrusor muscle of patients with bladder outlet obstruction (BOO) due to benign prostate hyperplasia (BPH); correlation with the urodynamic parameters.''. In World Journal of Urology. Springer Science and Business Media LLC. https://doi.org/10.1007/s00345-022-04181-2