Hyperuricemia significantly associated with erectile dysfunction in T2DM patients: Study
The proportion of men with hyperuricemia showing symptoms of erectile dysfunction is significant in type-2 diabetic patients, suggests a study published in the Andrology.
There has not been much evidence on whether and to what extent an association exists between hyperuricemia and erectile dysfunction (ED).
A study was conducted by a group of researchers from the University of L'Aquila to define pooled prevalence estimates and correlates of ED in men with hyperuricemic disorders.
The researchers performed a thorough search of Medline, Scopus and Cochrane Library databases were performed. Data were combined using random-effects models and the between-study heterogeneity was assessed by the Cochrane's Q and I2 tests. Funnel plot was used to assess publication bias.
The results of the study are as follows:
Overall, 8 studies included gave information about 85,406 hyperuricemic men, of whom 5,023 complained of erectile dysfunction (ED), resulting in a pooled erectile dysfunction (ED) prevalence estimate of 33%.
The funnel plot suggested the presence of a publication bias. At the meta-regression analyses, among the available covariates that could affect estimates, only type 2 diabetes mellitus (T2DM) was significantly associated with a higher prevalence of erectile dysfunction (ED).
At the sub-group analysis, the pooled erectile dysfunction (ED) prevalence decreased to 4% when only the largest studies with the lowest prevalence of type-2 diabetes (T2DM) were included and increased up to 50% when the analysis was restricted to studies enrolling smaller series with higher prevalence of type-2 diabetes (T2DM).
The researchers concluded that a not negligible proportion of men with hyperuricemia can complain of erectile dysfunction (ED). While a pathogenetic contribution of circulating uric acid in endothelial dysfunction cannot be ruled out, the evidence of a stronger association between hyperuricemia and erectile dysfunction (ED) in type-2 diabetes (T2DM) points to hyperuricemia as a marker of systemic dysmetabolic disorders adversely affecting erectile function.
Reference:
A study titled. "Erectile dysfunction in hyperuricemia: A prevalence meta-analysis and meta-regression study" by M. Totaro,S published in the Andrology.
https://doi.org/10.1111/andr.13088
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.