Low Doses of 5-ARIs Linked to Higher Suicide Risk, Lower Cardiovascular Mortality: Study Finds
South Korea: New data on 5 alpha -reductase inhibitors (5-ARIs) reveals that low cumulative doses are associated with an increased risk of suicide but a decreased risk of cardiovascular mortality in patients with benign prostatic hyperplasia (BPH) or androgenic alopecia (AGA).
The findings, published in Scientific Reports, stress the need for careful monitoring of patients undergoing treatment with these medications, especially given the increased risk of suicide associated with certain dosage levels.
5α-reductase inhibitors, widely prescribed for benign prostatic hyperplasia and androgenic alopecia, have been associated with a range of health outcomes, raising concerns about their long-term safety. However, the relationship between varying cumulative doses of 5-ARIs and mortality risk remains unclear. To explore this further, Eun-Cheol Park, Institute of Health Services Research, Yonsei University, Seoul, Republic of Korea, and colleagues conducted a nested case-control study aimed at evaluating both absolute and time-averaged cumulative doses of 5-ARIs and their potential association with all-cause and cause-specific mortality in patients diagnosed with BPH or AGA.
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