Rezum Water Vapor Thermal Therapy Improves BPH Symptoms: Study

The researchers included a total of 197 subjects >50 years of age, with IPSS ≥13, maximum flow rate (Qmax) ≤15 mL/s and prostate volume 30 to 80 cc. The subjects were randomized and followed for 5 years. From the 61 subject control arm, a subset of 53 subjects requalified and after 3 months, received treatment as part of the crossover group and were also followed for 5 years. The researchers determined the total number of vapor treatments to each lobe of the prostate by the length of the prostatic urethra and included middle lobe treatment per physician discretion.

Key findings of the study were:

• Upon analysis, the researchers observed a significant improvement of LUTS at <3 months post thermal therapy, remaining durable through 5 years in the treatment group (IPSS reduced 48%, Quality of life increased by 45%, Qmax improved 44%, BPHII decreased 48%).
• They noted that the surgical retreatment rate was 4.4%, with no reports of device or procedure-related sexual dysfunction or sustained de novo erectile dysfunction.
• They observed similar results within the crossover group for 5 years.

The authors concluded, "Minimally invasive treatment with Rezum water vapor thermal therapy provides significant and durable symptom relief as well as flow rate improvements through 5 years, with low surgical retreatment rates and without impacting sexual function. It is a versatile therapy, providing successful treatment to obstructive lateral and middle lobes."

For further information:

https://www.auajournals.org/doi/10.1097/JU.0000000000001778