Second-generation antiandrogens may increase cognitive decline, fatigue and falls in patients with prostate cancer
According to an Original Investigation published in JAMA Oncology, researchers have concluded that prostate cancer patients treated with second-generation antiandrogens (AAs) are at greater risk of cognitive or functional toxic effects, including fatigue and falls, in their systematic review and meta-analysis of 12 randomized clinical trials of 13 524 participants.
Using second-generation antiandrogens (AAs) for treating prostate cancer is increasing. Previous research has mentioned an association between second-generation AAs and adverse cognitive and functional outcomes. There is a lack of evidence and data from prospective trials.
In this study, researchers determined if evidence from randomized clinical trials (RCTs) in prostate cancer supports an association between second-generation AAs and cognitive or functional toxic effects.
For this, researchers collected data from PubMed, EMBASE, and Scopus. They included RCTs of second-generation AAs (abiraterone, apalutamide, darolutamide, or enzalutamide) among prostate cancer patients that evaluated cognitive toxic effects, asthenic toxic effects (e.g., fatigue, weakness), or falls.
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