Testosterone therapy not linked to recurrence of prostate cancer after treatment: Study
USA: Testosterone therapy(TT) is safe after definitive treatment of localized prostate cancer in appropriate patients, suggests a recent study in the journal Prostate Cancer and Prostatic Diseases. According to the study, after surgery or radiation, TT did not increase the risks of prostate-cancer specific or overall mortality and biochemical recurrence.
Reith R. Sarkar, University of California San Diego, La Jolla, CA, USA, and colleagues analyzed the risks of biochemical recurrence and mortality in men receiving TT after treatment for localized prostate cancer.
Cohort analysis was conducted using the US Veterans Affairs Informatics and Computing Infrastructure. The researchers identified 69,984 patients having localized prostate cancer and were treated with radiation or surgery. Receipt of TT was coded after treatment as a time-dependent covariate. The National Death Index fused to identify the cause of death and defined biochemical recurrence as PSA > 0.2 ng/mL after surgery and nadir + 2 ng/mL after radiation. Using cumulative incidence curves, Fine–Gray competing risk regression, and Cox regression, the researchers analyzed recurrence and mortality.
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