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Ropivacaine & Diprospan infiltration Effective In reducing Pain score After Craniotomy
Many sources suggest that patients undergoing craniotomy experience significant postoperative pain. A prospective study showed that up to 80% of patients experience mild to severe pain in the acute postoperative period.
A recent study suggests that diprospan and ropivacaine preemptive scalp infiltration is an effective technique for postoperative analgesia after craniotomy. The study findings were published in the journal Anesthesia and Analgesia on March 18, 2022.
Diprospan is a combination of quick-acting betamethasone sodium phosphate and long-acting betamethasone dipropionate. Whether Diprospan as an adjuvant to local anesthetic can achieve post craniotomy pain relief has not been studied yet. Therefore, Dr Xueye Han and her team conducted a study to assess the treatment effect of preemptive incision-site infiltration of ropivacaine plus Diprospan (versus ropivacaine alone) on postoperative analgesia for patients undergoing craniotomy.
In this prospective, single-centre, blinded, randomized, controlled clinical study, the researchers included 96 patients with the American Society of Anaesthesiologists (ASA) physical statuses of I to III, scheduled for elective supratentorial craniotomy. The patients were randomly assigned to either the Diprospan group, who received incision-site infiltration of 0.5% ropivacaine plus Diprospan (n = 48), or the control group, who received 0.5% ropivacaine alone (n = 48), with a distribution ratio of 1:1. The major outcome assessed was the cumulative sufentanil (μg) consumption through patient-controlled analgesia (PCA) within 48 hours after surgery. They performed a primary analysis based on the intention-to-treat (ITT) principle.
Key findings of the study:
- The researchers noted that the baseline characteristics were not significantly different between the 2 groups.
- In the Diprospan group, they found that the cumulative sufentanil consumption through PCA was 5µg within 48 hours postoperatively, which was significantly lower than that in the control group (38µg).
The authors concluded, "This study demonstrates that local infiltration of ropivacaine and Diprospan significantly decreases analgesic consumption within 48 hours postoperatively, reduces pain scores within 72 hours postoperatively, and achieves patient analgesia satisfaction when compared to ropivacaine infiltration alone; therefore, it is expected to be an alternative for postoperative analgesia."
For further information:
DOI: 10.1213/ANE.0000000000005971
Keywords:
Ropivacaine, Diprospan, pain scores, Pain management, postoperative analgesia, Anesthesia and Analgesia, craniotomy, incision-site infiltration, patient-controlled analgesia, Sufentanil (μg) consumption.
Medical Dialogues Bureau consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers. Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751