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  • Evolocumab has no...

Evolocumab has no negative impact on cognitive function among paediatric patients with FH

Written By : Aditi |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-11-08T03:00:53+05:30  |  Updated On 8 Nov 2023 3:00 AM IST
Evolocumab has no negative impact on cognitive function among paediatric patients with FH
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PCSK9 inhibition with evolocumab reduces low-density lipoprotein cholesterol in adults and children with familial hypercholesterolaemia (FH). The HAUSER-RCT found that 24 weeks of treatment did not impact cognitive function in children.

Evolocumab treatment did not affect cognitive functions like learning, psychomotor function, executive function and attention, says Dr Raul D Santos, MD, PhD, in a recent study published in The European Journal of Preventive Cardiology.

HAUSER-OLE was an 80-week open-label extension of HAUSER-RCT. This randomized, double-blind, 24-week trial evaluated the efficacy and safety of evolocumab in children aged 10 to 17 years with FH. All patients received monthly subcutaneous injections of 420 mg of evolocumab. Psychomotor function, attention, visual learning, and executive function tests were administered at baseline and weeks 24 and 80 of the OLE. Descriptive analysis and ANCOVA analyzed changes over time, and Cohen’s d statistic was employed to determine the magnitude of treatment effects.

Key findings from the study are:

  • ANCOVA results indicated no decrease in performance across visits during 80 weeks of evolocumab treatment for a computerized battery of cognitive tests, including Groton Maze Learning (executive function), One Card Learning accuracy (visual learning), Identification speed (visual attention), or Detection speed (psychomotor function).
  • Performance on all tasks was similar for those who received placebo or evolocumab in the RCT.
  • For all tests, the least square mean differences between patients taking placebo vs evolocumab were trivial (parent study).

In this study, they tested whether treating children with evolocumab for 80 weeks affected their mental ability to perform several tasks. A battery of tests showed no decrease in performance across visits during 80 weeks of evolocumab treatment.

Reference:

Raul D Santos et al. Evolocumab in paediatric heterozygous familial hypercholesterolaemia: cognitive function during 80 weeks of open-label extension treatment, European Journal of Preventive Cardiology, 2023; zwad332, https://doi.org/10.1093/eurjpc/zwad332


Evolocumabpediatric patientscognitive functionfamilial hypercholesterolaemiaThe European Journal of Preventive CardiologyHAUSER-OLEHAUSER-RCT
Source : The European Journal of Preventive Cardiology
Aditi
Aditi

    BDS, MDS in Periodontics and Implantology

    Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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