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  • Ezetimibe safe...

Ezetimibe safe treatment option for patients who need lipid-lowering treatment

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-05-10T11:15:26+05:30  |  Updated On 3 Jan 2024 4:02 PM IST
Ezetimibe safe treatment option for patients who need lipid-lowering treatment
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According to a recent study published in BMJ Medicine, ezetimibe is safe in patients who need lipid-lowering treatment.

A study was conducted to determine the harms of ezetimibe in people who need lipid-lowering treatment. Studies comparing ezetimibe with placebo, standard care, or other lipid-lowering agents in people who need lipid-lowering treatment with a follow-up duration of at least six months (or 24 weeks). The relative effects for potential harms of ezetimibe were pooled using random effect pairwise meta-analyses for randomised controlled trials. The evidence from observational studies was narratively summarised. The certainty of the evidence was assessed using the Grading of Recommendation Assessment, Development, and Evaluation.

Results:

  • 48 randomised controlled trials with 28 444 participants (median follow-up 34 weeks, range 24-312 weeks) and four observational studies with 1667 participants (median follow-up 282 weeks, range 72-400 weeks) were included.
  • The meta-analyses of randomised trials showed moderate to high certainty that ezetimibe was not associated with cancer (relative risk 1.01; 95% confidence interval 0.92 to 1.11), fractures (0.90; 0.74 to 1.10), discontinuation due to any adverse event (0.87; 0.74 to 1.03), gastrointestinal adverse events leading to discontinuation (1.34; 0.58 to 3.08), myalgia or muscular pain leading to discontinuation (0.82; 0.51 to 1.33), neurocognitive events (1.48; 0.58 to 3.81), or new-onset diabetes (0.88; 0.61 to 1.28).
  • The narrative analysis of observational studies provided consistent findings.
  • No credible subgroup effects were identified for the harm outcomes, including shorter versus longer follow-up duration of trials.

Thus, Ezetimibe results in little to no difference in adverse events or other undesirable effects compared with placebo, usual care or other lipid-lowering agents.

Reference:

Safety of ezetimibe in lipid-lowering treatment: systematic review and meta-analysis of randomised controlled trials and cohort studies by Yang Wang et al. published in the BMJ Medicine.



Safetyezetimibelipid-lowering treatmentBMJ Medicine
Source : BMJ medicine
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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