High density PRISM mapping improves ablation results for persistent AF: JAMA

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-11-27T10:00:52+05:30 | Updated On 27 Nov 2023 12:52 PM IST

Persistent atrial fibrillation (AF), a challenging condition to manage, has often shown limited response to catheter ablation. A novel approach known as periodicity and similarity (PRISM) mapping has demonstrated remarkable success in a prospective randomized clinical trial for Persistent AF treatment, conducted across three centers in Asia. The outcomes were published in Journal of American Medical Association.

In this trial conducted between June 2019 and December 2020, patients were assigned to either the PRISM-guided approach (group 1) or the conventional approach (group 2) at a 1:1 ratio. The primary outcome measured was freedom from AF or other atrial arrhythmias lasting longer than 30 seconds at 6 and 12 months.

The results found that patients in the PRISM-guided group exhibited a significantly higher rate of freedom from AF at the 12-month mark compared to those in the conventional group (70.6% vs. 47.1%). Multivariate analysis further underscored the efficacy of the PRISM-guided approach, revealing a hazard ratio of 0.53 (95% CI, 0.33-0.85), signifying a substantial reduction in the recurrence of atrial arrhythmias.

The PRISM mapping technique, which analyzes waveform similarity and recurrence patterns through high-density mapping, offers a promising advancement in guiding the ablation process for persistent AF. This specific substrate ablation strategy not only reduced the frequency of recurrent AF but also increased the likelihood of maintaining sinus rhythm.

This study is important in the field of AF treatment, providing hope for improved outcomes and potentially paving the way for a more effective and targeted approach to catheter ablation. As the medical community eagerly awaits further validation and adoption of this innovative strategy, the PRISM mapping approach emerges as a beacon of progress in the evolving landscape of cardiac arrhythmia management.

Reference:

Lin, C.-Y., Lin, Y.-J., Higa, S., Tsai, W.-C., Lo, M.-T., Chiang, C.-H., Chang, S.-L., Lo, L.-W., Hu, Y.-F., Chao, T.-F., Chung, F.-P., Liao, J.-N., Chang, T.-Y., Lin, C., Tuan, T.-C., Kuo, L., Wu, C.-I., Liu, C.-M., Liu, S.-H., … Chen, S.-A. (2023). Catheter ablation with morphologic repetitiveness mapping for persistent atrial fibrillation. JAMA Network Open, 6(11), e2344535. https://doi.org/10.1001/jamanetworkopen.2023.44535

JAMA Network OpenPRISM mappingPersistent atrial fibrillation

Source : JAMA Network Open

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751