Higher long-term hair glucocorticoid levels may reflect elevated risk of heart diseases

Netherlands: New research has revealed that measuring glucocorticoid levels in individuals' hair may predict future cardiovascular disease (CVD) risk. The findings were presented at the European Congress on Obesity (ECO) in Dublin, Ireland, held from 17-20 May 2023.

"Our findings suggest that glucocorticoid levels (a class of steroid hormones secreted as a response to stress) present in the hair of individuals may indicate which of them are more likely to suffer from cardiovascular diseases in the future," the researchers wrote in the study.

“There is a tremendous amount of evidence that chronic stress is a serious factor in determining overall health. Our findings indicate that people with higher long-term hair glucocorticoid levels appear significantly more likely to develop heart and circulatory diseases,” says lead author Dr Eline van der Valk from Erasmus University Medical Center Rotterdam in the Netherlands.

Long-term levels of scalp hair cortisol and its inactive form, hair cortisone, are increasingly used biomarkers representing cumulative exposure to glucocorticoids over the previous months.

A large body of evidence indicates that the stress hormones cortisol and cortisone affect the body’s metabolism and fat distribution. But data on these stress hormone levels and their effect on long-term CVD outcomes is scarce.

To find out more, researchers analysed cortisol and cortisone levels in 6,341 hair samples from adult men and women (aged 18 and older) enrolled in Lifelines-a multi-generational study including over 167,000 participants from the northern population of the Netherlands.

Study participants' hair was tested, and participants were followed for an average 5-7 years to assess the long-term relationship between cortisol and cortisone levels and incident CVD. During this time, there were 133 CVD events.

Researchers adjusted for factors known to be linked with increased risk of CVD including age, sex, waist circumference, smoking, blood pressure, and type 2 diabetes.

The researchers found that people with higher long-term cortisone levels were twice as likely to experience a cardiovascular event like a stroke or heart attack, and this rose to over three times as likely in those aged 57 years or younger.

However, in the oldest half of CVD cases (aged 57 and older), hair cortisone and cortisol were not strongly linked to incident CVD.

“Our hope is that hair analysis may ultimately prove useful as a test that can help clinicians determine which individuals might be at high risk of developing cardiovascular disease. Then, perhaps in the future targeting the effects of stress hormones in the body could become a new treatment target,” says Professor Elisabeth van Rossum, the principal investigator of the study from Erasmus University Medical Center.

The authors acknowledge several limitations of the study, including that it is observational and does not prove that stress causes CVD but indicate that they are linked. They also note that most participants self-identified as white and were from one area of the Netherlands so the findings might not be generalisable to other populations. And although age, sex, waist circumference, smoking, blood pressure, and type 2 diabetes were adjusted for in the analysis, there may be other unmeasured factors that may have influenced the results.

Reference:

Stress hormone measured in hair predicts who is likely to suffer from cardiovascular diseases, European Association for the Study of Obesity, Meeting, European Congress on Obesity (ECO2023).