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  • Longer leukocyte...

Longer leukocyte telomere length associated with better cardiac function and lower risk of incident HF: JAMA

Written By : Aditi |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 12 Aug 2023 5:00 AM  |  Updated On 12 Aug 2023 6:40 AM
Longer leukocyte telomere length  associated with better cardiac function and lower risk of incident HF: JAMA
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An Original Investigation published on July 26, 2023, in JAMA Cardiology entitled "Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure" by Dr Nay Aung and colleagues has highlighted there is a role of modulation of leukocyte telomere length or LTL dynamics in improving cardiovascular structure and function.

There is an association between LTL and a lower risk of adverse cardiovascular outcomes. There needs to be more clarity on the extent to which LTL variation is associated with intermediary cardiovascular phenotypes.

The main research question is whether LDL is associated with cardiovascular structure and function changes.

This background was researched in this study of 40 459 UK Biobank participants. Researchers measured LTL using a quantitative PCR method. Cardiovascular imaging traits and heart failure were the primary outcomes measured.

The key results of the study are:

  • The study had 19 529 men of mean age 55 years, constituting 48%.
  • Longer LTL was associated with a pattern of positive cardiac remodelling (higher left ventricular mass, larger global ventricular size and volume, and higher ventricular and atrial stroke volumes) and a lower risk of incident HF.
  • There was a potential causal association between LTL and left ventricular mass, global ventricular volume, and left ventricular stroke volume.

Concluding further, they said, We found an association of longer LTL with a larger heart wand better cardiac function in middle age.

The findings of this study explain the reduced incidence of heart failure.

They said, “To our knowledge, this is the first and largest study to investigate the potential causal association between LTL and a comprehensive set of cardiac structure and function, robustly measured with CMR.”

The study’s strengths include the largest sample size and application of MR for potential causal inference analysis using data from recent extensive genome-wide association studies.

Further reading:

Aung N, Wang Q, van Duijvenboden S, et al. Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure. JAMA Cardiol. Published online July 26, 2023. doi:10.1001/jamacardio.2023.2167

LTL dynamicsmodulation LTLheart failureJAMA Cardiologyleft ventricular massglobal ventricular volumeleft ventricular stroke volume
Source : JAMA Cardiology
Aditi
Aditi

    BDS, MDS in Periodontics and Implantology

    Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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