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Low circulating vitamin D levels tied to risk of cardiovascular disease: Study
Australia: A recent study has found that low levels of circulating vitamin D are associated with a higher risk of cardiovascular disease (CVD) incidence events and recurrent CVD events. The study appears in the journal Nutrition, Metabolism & Cardiovascular Diseases.
"Our findings are valuable for understanding the vitamin D-CVD relationship as in the study, CVD outcomes were examined as fatal, non-fatal/recurrent, and combined (fatal and non-fatal/ recurrent) events," Rati Jani, Faculty of Health, Department of Nutrition and Dietetics, University of Canberra, Australia, and the team wrote in their study.
Previous studies have shown a link between circulating vitamin D and the risk of CVD. However, no meta-analysis has yet explored the correlation between vitamin D and the risk of CVD incidence and recurrent CVD. Considering this, Dr. Jani and the colleagues aimed to examine the association between 25-hydroxy-vitamin D (25(OH)D) and the risk of CVD incidence (fatal, non-fatal, fatal, and non-fatal combined events) and the risk of recurrent CVD (fatal, recurrent, and fatal and recurrent combined events).
The meta-analysis included a total of 79 studies (46 713 CVD cases in 1 397 831 participants), of which 61 studies examined the risk of CVD incidence events, and 18 studies examined the risk of recurrent CVD events.
Following were the study's key findings:
- Low 25(OH)D was associated with 34% and 86% higher risk of CVD incidence and recurrent CVD events.
- Low 25(OH)D may have more (86% vs 34%) detrimental outcomes on the risk of recurrent CVD event than CVD incidence event.
- Every 10 ng/ml increment of 25(OH)D was associated with a 6% lower risk of non-fatal CVD incidence event.
- Every 10 ng/ml increment of 25(OH)D was associated with a 55% reduction in the risk of recurrent fatal CVD events.
- Every 10 ng/ml increment of 25(OH)D was associated with a 20% reduction in the risk of recurrent combined CVD event.
"To our knowledge, this is the first study reporting the association between 25(OH)D and the risk of both CVD incidence events and the risk of recurrent CVD events," the authors wrote.
"The lowest category of circulating 25(OH)D was shown to be associated with a higher risk of CVD incidence events and recurrent CVD events," they concluded.
Reference:
The study titled, "Circulating 25-hydroxy-vitamin D and the risk of cardiovascular diseases. Systematic review and meta-analysis of prospective cohort studies," was published in the journal Nutrition, Metabolism & Cardiovascular Diseases.
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751