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Migraine lowers death risk in stress induced 'Takotsubo' cardiomyopathy
USA: Takotsubo cardiomyopathy (TCM) patients with migraine have lower odds of mortality and acute complications (heart failure exacerbation, cardiac arrest, acute kidney injury) versus TCM patients without migraine, a recent study has claimed. The study was published online in the journal Cardiovascular Revascularization Medicine on March 24, 2022.
Takotsubo cardiomyopathy or "Broken Heart Syndrome" is an acute left ventricular dysfunction that is typically due to a neuro-cardiogenic mechanism. The role of migraines in hospitalized TCM patients has not been studied although many stressors can precipitate TCM. Considering this, Jobin Joseph Varghese, MedStar Washington Hospital Center, Washington, DC, USA, and colleagues aimed to describe the in-hospital outcomes of TCM in patients with a concurrent diagnosis of migraines.
For this purpose, the researchers queried the National Inpatient Sample database for the International Classification of Diseases-ninth Revision to conduct a US-wide analysis of TCM hospitalizations from 2013 to 2017. Using the ICD-10 codes, they identified patients admitted with a principal diagnosis of TCM with a history of migraines.
The comparison was then made between TCM patients with migraines and TCM patients without migraines with regards to mortality and acute inpatient complications (intubation, cardiac arrest, heart failure exacerbation, acute kidney injury).
A total of 172,025 TCM patients were identified, of these, 3610 suffered from migraines.
Based on the study, the researchers found the following:
- TCM patients with a diagnosis of migraine were associated with a lower odd for mortality (OR: 0.388) and acute complications (OR: 0.511) compared to those without migraines.
- After adjusting for confounders, the adjusted odds ratio for mortality was 0.622, and acute complications were 0.563.
"There is limited research that describes a link between migraines and TCM, and to the best of our knowledge, this is the largest study investigating the relationship between migraines and TCM," the authors write.
"Further studies are required to investigate this association of migraine and its protective neurohormonal effects on TCM patients," they concluded.
Reference:
Varghese JJ, Yacob O, Frances BS, Garcia-Garcia HM. Impact of migraine headaches on stress induced 'Takotsubo' cardiomyopathy. Cardiovasc Revasc Med. 2022 Mar 14:S1553-8389(22)00116-6. doi: 10.1016/j.carrev.2022.03.005. Epub ahead of print. PMID: 35337755.
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751