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Patients with severe infections at increased risk of major CV events after hospitalization

Written By : Dr. Mahalakshmi Sivashankaran |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-03-31T11:00:39+05:30  |  Updated On 31 March 2023 11:56 AM IST
Patients with severe infections at increased risk of major CV events after hospitalization
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Finland: A new study has revealed that infections severe enough to require hospital treatment are associated with an increased risk of major cardiovascular events after hospitalization, both in the short term and the long term, pointed out a study published in Circulation- American Heart Association Journal.

Hospitalized patients with severe bacterial or viral infections hospitalized over a month have an increased risk of experiencing a cardiovascular event, according to a UK Biobank analysis.

The study was a Multicohort study and estimated the population-attributable fraction for severe infections and major cardiovascular events using data from over 331,683 participants in the UK Biobank study and over 271,533 participants in three prospective cohort studies in Finland.

Researchers measured baseline cardiovascular risk factors and linked participants to hospital and mortality registers to diagnose infections and major cardiovascular events.

The study found the following clinical findings:

  1. The study found that of the 54,434 participants who had been hospitalized for an infection, 11649 participants experienced an increased risk of major cardiovascular events compared to those without a record of infectious disease.
  2. The association was strongest during the first month after infection but remained elevated throughout the follow-up period. The findings were similar in both the UK Biobank and the replication cohort.
  3. After adjusting for traditional cardiovascular risk factors, the researchers estimated that severe infections were responsible for 4.4% of major cardiovascular events in the UK Biobank and 6.1% in the replication cohort.

The findings have far-reaching implications for public health. According to the findings, healthcare providers should be aware of the increased risk of major cardiovascular events in patients who have been hospitalized for an infection and should take steps to monitor and manage their patient’s cardiovascular health.

“The study emphasizes the importance of infection prevention and treatment in lowering the risk of cardiovascular disease. However, the study also stated the residual confounding could not be ruled out, implying that other factors could have influenced the findings,” said Dr. Pyry Sipilä, the study's lead author.

Reference:

Sipilä PN, Lindbohm JV, Batty GD, et al. Severe infection and risk of cardiovascular disease: a multicohort study. Circulation. 2023; Epub DOI: https://doi.org/10.1161/CIRCULATIONAHA.122.061183


major cardiovascular eventsMACEhospitalized patientsSevere infectionscirculation journalAHAAmerican Heart AssociationUK Biobankpublic healthinfections
Source : Circulation- AHA Journal
Dr. Mahalakshmi Sivashankaran
Dr. Mahalakshmi Sivashankaran

    Dr. Mahalakshmi Sivashankaran joined Medical Dialogues as an Intern in 2023. She is a BDS graduate from Manipal College of Dental Sciences, Mangalore Batch 2022, and worked as a Junior Resident at VMMC & Safdarjung Hospital at the Department of Dental Surgery till January 2023. She has completed a Diploma in Executive Healthcare management from the Loyola Institute of Business Administration, developing skills in Healthcare Management and Administration. She covers several medical specialties including Dental, ENT, Diagnostics, Pharmacology, Neurology, and Cardiology.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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