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  • Promising treatment...

Promising treatment for refractory ventricular tachycardia shown in first-in-human trial

Written By : Dr. Kamal Kant Kohli Published On 2022-08-18T19:30:43+05:30  |  Updated On 18 Aug 2022 7:30 PM IST
Promising treatment for refractory ventricular tachycardia shown in first-in-human trial
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Ventricular tachycardia is an abnormally rapid heart rhythm that is a leading cause of sudden cardiac death worldwide.

Researchers at Mayo clinic have used a new ablation technique for patients with ventricular tachycardia in a first-in-human multicenter trial.

The trial tested needle ablation using in-catheter, heated, saline-enhanced, radio frequency energy to substantially increase heat transfer, compared to conventional ablation methods.

The new process produces deeper, controllable lesion scars at sites inside the heart muscle. The catheter can accurately control the ablation size and treat tissue that is deeper in the heart wall, which is where life-threatening arrhythmias that cause ventricular tachycardia are often found.

Therapies of medication and traditional ablation, which uses heat or cold to scar small areas of heart tissue, may not be enough to prevent ventricular tachycardia. Therefore, many patients also have an implantable cardioverter-defibrillator (ICD) to address dangerous arrhythmias. While an ICD shock corrects the heart's rhythm, it does not prevent arrhythmia. In the trial, researchers used several methods to directly eliminate abnormal heart tissue that causes life-threatening rhythm.

"This preliminary trial is important because it suggests that there is a new way to treat problematic ventricular tachycardia by reducing or eliminating the shocks that ICDs deliver. It appears to be effective in achieving this goal," says Douglas Packer, M.D., a cardiac electrophysiologist at Mayo Clinic, first author and principal investigator of the study. "For clinicians, it provides hope that treatment in the electrophysiology lab may be effective, even if other treatments failed. For patients, it provides hope that their quality of life can be improved."

The innovative catheter was developed by Michael Curley, Ph.D., of Boston-based Thermedical Inc., with funding from the National Institutes of Health (NIH). Dr. Curley is senior author of the research findings that are published in Circulation: Arrhythmia and Electrophysiology.

In the trial, 32 participants from six centers underwent needle electrode ablation. Each had experienced multiple episodes of ventricular tachycardia that did not respond to drug therapy after an ICD was implanted and standard ablation was done. These patients had about 45 shocks from their defibrillator in the six months before their procedure.

For 31 of these 32 patients, their clinical ventricular tachycardia was eliminated immediately at the end of the procedure. Device therapies, such as shock or pace regulation, were reduced by 89% during the five-month follow-up period. Five patients in this high-risk group had complications, primarily in the earlier procedures.

People with ventricular tachycardia live with the potential of sudden cardiac death from irregular electrical signals in the heart. Shocks from an ICD are used to stop arrhythmia, but they do not eliminate the cause of arrhythmia. Corrective shocks are stressful for patients and can reduce quality of life, especially if needed frequently.

"Patients need better treatments for ventricular tachycardia," says Emily Tinsley, Ph.D., a program officer in the Heart Failure and Arrhythmias Branch of the Division of Cardiovascular Sciences in the National Heart, Lung, and Blood Institute, part of the NIH. Dr. Tinsley was not a member of the study team. "While more research is needed to confirm the findings, this trial gives us preliminary information about a promising new technology for treating this condition."

Dr. Packer says the next step in this research is a larger clinical trial with approximately 150 patients to prove the findings and demonstrate the safety of the new SERF technology.

Reference:

Douglas L Packer, David J Wilber, Suraj Kapa, Katia Dyrda, Isabelle Nault, Ammar M Killu, Arvindh Kanagasundram, Travis Richardson, William Stevenson, Atul Verma, Michael Curley,

DOI: 10.1161/CIRCEP.121.010347



ventricular tachycardiaheart rhythmscardiac deatharrhythmiasablationmuscle tissueCirculation
Source : Circulation
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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