- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Researchers identify new biomarkers for coronary microvascular disease
USA: The researchers have identified specific biomarkers for coronary microvascular disease (CMD) that might reduce future hospitalizations in postmenopausal women, according to a recent study in the journal Metabolites.
The newly identified biomarkers are significant because though CVD is the main cause of illness among women in the US, certain conditions such as CMD are not easily diagnosable.
CMD damages the inner walls of blood vessels causing spasms and decreased blood flow to the heart muscle. "Clinicians look for plaque formation in the blood vessels, which does not occur in CMD," said Zeynep Madak-Erdogan (CGD/EIRH/GSP), an associate professor of nutrition. "Usually, women leave without having the root causes of the chest pain addressed and they come back with further complications within a year. Since this condition is more common in postmenopausal women, we want to identify the biomarkers that are associated with CMD."
The researchers collected blood samples from three different groups containing 20-25 women each: postmenopausal women who were healthy, those with coronary artery disease, which is characterized by plaque formation, and those with CMD. The blood serum samples were then analyzed to see if there were any molecules that were different in the CMD group.
Out of 175 molecules scanned, the researchers identified stearic acid, which is found in animal and plant fats, and ornithine, an amino acid commonly found in meat, fish, diary, and eggs, as indicators of CMD.
Ornithine is formed from the amino acid arginine which is broken down by two separate pathways. One forms ornithine and the other forms nitric oxide, which helps in maintaining the normal functioning of the blood vessels.
"Our observations imply that the increase in ornithine means that the second branch is not working, which is why we can use this molecule as a biomarker for the disease," Madak-Erdogan said.
Interestingly, other researchers have found that estrogen may have a role in the development of CMD, as evidenced by hormone-replacement therapies which decrease CMD risk up to 30%. "Our observations further indicate that estrogen is involved because we know that it improves the function of nitric oxide," Madak-Erdogan said. "Since postmenopausal women have lower levels of estrogen, it would explain why this condition is more prevalent in these populations."
The researchers are trying to identify more biomarkers, such as proteins, that can be used to detect CMD. Additionally, they are testing more women to validate their findings. "This study was done with patients in Turkey, so we don't know if the same biomarkers will be present in the U.S. We want to look at bigger populations to see if we can combine the data to find efficient signatures for CMD," Madak-Erdogan said.
Reference:
The study titled "Identification of circulating diagnostic biomarkers for coronary microvascular disease in postmenopausal women using machine-learning techniques" is published in the journal Metabolites.
DOI: https://www.mdpi.com/2218-1989/11/6/339
Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email:Â editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751