Selenium deficiency associated with anemia among hospitalized heart failure patients

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-02-02T10:45:52+05:30 | Updated On 2 Feb 2024 12:36 PM IST

A recent study published in the ESC Heart Failure highlights the intricate relationship between selenium levels and anemia in heart failure (HF) patients. Based on the findings from the BIOSTAT-CHF study, the research reveals important insights into how selenium deficiency contributes to the severity of anemia in individuals with heart failure.

Heart failure patients usually face a challenging prognosis, with increased hospitalization rates, decreased exercise tolerance and higher mortality. But, this new study underlines the significance of selenium in reducing these adverse outcomes. The study was conducted on 320 hospitalized HF subjects and found that higher levels of selenoprotein P (SELENOP) which is a crucial biomarker for selenium transport, were associated with a lower risk of anemia and iron deficiency.

The comprehensive analysis considered SELENOP concentrations in relation to hemoglobin (Hb) levels, the prevalence of anemia and iron status, as measured by the transferrin receptor 1 (TfR1). The results revealed a clear correlation between SELENOP levels and these crucial health markers.

It was also discovered that SELENOP concentrations were positively correlated with hemoglobin concentrations which provides evidence that adequate selenium levels may positively influence blood health. However, SELENOP deficiency was associated with lower hemoglobin concentrations, higher TfR1 concentrations indicative of iron deficiency and a higher risk of anemia in HF patients.

These findings emphasize the role of selenium in the overall health management of the heart failure patients. SELENOP appears to be a critical player in widely reducing the risk of anemia and targeted interventions to improve the patient outcomes. This research deepens our understanding of the potential connections between selenium, anemia and heart failure and additionally paves the way for future interventions by optimizing selenium levels in HF patients that could improve their overall prognosis.

Reference:

Jujić, A., Molvin, J., Holm Isholth, H., Dieden, A., Korduner, J., Zaghi, A., Nezami, Z., Bergmann, A., Schomburg, L., & Magnusson, M. (2024). Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients. ESC Heart Failure. https://doi.org/10.1002/ehf2.14651

ESC Heart Failureselenium deficiencyAnemia in heart failure patients

Source : ESC Heart Failure

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751