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Shockwave intravascular lithotripsy-assisted TMVR promising for patients with severe mitral annular calcification

Written By : Dr. Kamal Kant Kohli Published On 2023-01-13T10:00:14+05:30  |  Updated On 13 Jan 2023 11:48 AM IST
Shockwave intravascular lithotripsy-assisted TMVR promising for patients with severe mitral annular calcification
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Although transcatheter mitral valve replacement (TMVR) treatment and technology has evolved In recent years but procedure-related morbidity is a matter of concern.

According to a new study shockwave intravascular lithotripsy-assisted TMVR was promising for patients with severe mitral annular calcification in a patient with severe stenosis and mitral regurgitation (MR).

The study has been published in the Journal of the Society for Cardiovascular Angiography & Interventions (JSCAI).

MR affects an estimated 4 million people in the United States. Mitral valve leaflets become damaged or stretched and the valve may not close properly, which allows blood to flow backward, causing MR. Aortic stenosis, which is a narrowed aortic valve that decreases blood flow from the heart to the body, impacts as many as 300,000 people per year.

An 83-year-old male had previously received transcatheter aortic valve replacement (TAVR) for aortic stenosis presented with medically refractory dyspnea. He was enrolled in the APOLLO trial of Intrepid valve TMVR. Transseptal implantation of a 48-mm Intrepid valve was facilitated by Shockwave IVL delivered via two (8.0 x 60-mm) M5 + balloons placed across the mitral annulus before implantation. Cerebral embolic protection during IVL and valve implant was provided by Sentinel device and left subclavian balloon occlusion, according to the researchers.

“Our team used IVL to modify this severely calcified mitral annulus and valve leaflets to facilitate expansion of the Intrepid self-expanding valve,” stated Dean Kereiakes, MD, MSCAI, lead author of the study and Medical Director of The Christ Hospital Heart and Vascular Center, Medical Director of the Christ Hospital Research Institute, and Professor of Clinical Medicine at Ohio State University. “This type of patient is often turned down for catheter-based therapies.”

Post-dilation achieved valve frame expansion and reduced MR. Post-procedural imaging performed before hospital discharge and at 30 days displayed progressive valve frame expansion in the anteroposterior dimension, increased valve area, and resolution of MR.

Researchers stated that further clinical research and studies will be needed before IVL can be considered as a routine accompaniment to TMVR in patients with severe mitral annular and leaflet calcification or before Sentinel and balloon occlusion of the left subclavian can be proven to provide cerebral embolic protection during TMVR.

Reference:

Puvi Seshiah, Santiago Garcia, Joseph Choo, J. Michael Smith, Geoffrey A. Answini, Terri Stewart, Dean J. Kereiakes, Published:January 10, 2023DOI: https://doi.org/10.1016/j.jscai.2022.100540

Journal of the Society for Cardiovascular Angiography & Interventionsstenosismitral valve replacementmitral regurgitationaortic stenosisrefractory dyspnea
Source : Journal of the Society for Cardiovascular Angiography & Interventions
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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