Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Cardiology-CTVS
  • Cardiology & CTVS News
  • Targeting SBP Below...

Targeting SBP Below 130 mmHg May Lower Hospitalizations in HFpEF Without Increasing Serious Risks: Meta-analysis

Dr. Prem AggarwalWritten by Dr. Prem Aggarwal Published On 2025-06-19T08:45:04+05:30  |  Updated On 19 July 2025 2:03 PM IST
Targeting SBP Below 130 mmHg May Lower Hospitalizations in HFpEF Without Increasing Serious Risks: Meta-analysis
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

Japan: Targeting a systolic blood pressure (SBP) below 130 mmHg may significantly reduce hospitalizations in patients with heart failure with preserved ejection fraction (HFpEF), a recent systematic review and meta-analysis published in Hypertension Research has revealed. The study, led by Dr. Chisa Matsumoto from the Department of Cardiology at Tokyo Medical University in Fukuoka, Japan, offers important guidance for clinicians ahead of the upcoming Japanese Society of Hypertension 2025 (JSH2025) guidelines.

HFpEF accounts for approximately half of all heart failure cases and remains a clinical challenge, particularly when it comes to optimal blood pressure management. To address this, Dr. Matsumoto and her team systematically reviewed randomized controlled trials (RCTs) published since 2012 that examined the impact of tight BP control, specifically targeting SBP <130 mmHg, on clinical outcomes in HFpEF patients.

The analysis included six RCTs that collectively assessed various interventions such as mineralocorticoid receptor antagonists, angiotensin receptor-neprilysin inhibitors (ARNIs), intensive BP control strategies, and comprehensive heart failure management approaches. These studies had follow-up periods of at least six months and demonstrated significant BP reduction in intervention groups, achieving SBP below 130 mmHg.

The study led to the following findings:

  • Maintaining systolic blood pressure (SBP) below 130 mmHg was associated with a 20% reduction in the risk of heart failure-related hospitalizations (RR: 0.80).
  • There was a trend toward reduced all-cause mortality, though it did not reach statistical significance.
  • There was a 35% increased risk of hypotension reported (RR: 1.35).
  • There was no significant increase in serious adverse events or renal dysfunction, suggesting overall safety was not compromised despite the lower SBP target.

Even though none of the trials were specifically designed to use SBP <130 mmHg as the primary intervention target, the consistent benefits observed across different treatment modalities support the adoption of this threshold in clinical practice for HFpEF patients.

“Based on our findings, we advocate aiming for an SBP under 130 mmHg in HFpEF management, provided that patients are carefully monitored for hypotension,” said Dr. Matsumoto. “Given the heterogeneity of HFpEF, personalized treatment strategies and close clinical observation remain essential.”

The authors call for future trials that directly assess SBP targets and investigate how different antihypertensive agents might be tailored to the complex needs of HFpEF patients.

The study provides timely evidence to inform treatment decisions and guideline development, emphasizing a cautious yet proactive approach to blood pressure control in heart failure care.

Reference:

Matsumoto, C., Nagai, M., Shinohara, K., Morikawa, N., Kai, H., & Arima, H. (2025). Systolic blood pressure lower than 130 mmHg in heart failure with preserved ejection fraction: A systematic review and meta-analysis of clinical outcomes. Hypertension Research, 1-14. https://doi.org/10.1038/s41440-025-02240-w


Hypertension Researchheart failure with preserved ejection fractionoptimal blood pressure (BP) management
Source : Hypertension Research
Dr. Prem Aggarwal
Dr. Prem Aggarwal

Dr Prem Aggarwal, (MD Medicine, DNB Cardiology) is a Cardiologist by profession and also the Co-founder and Chairman of Medical Dialogues. He focuses on news and perspectives about cardiology, and medicine related developments at Medical Dialogues. He can be reached out at drprem@medicaldialogues.in

Show Full Article
Next Story

Editorial

Penicillin-Binding Protein 3 Inserts in E.coli:A Growing Burden of Underreported Threat

Penicillin-Binding Protein 3 Inserts in E.coli:A Growing Burden of Underreported Threat

Management of Hypertension: How Innovative Packaging Can Improve Patient Outcomes?

Management of Hypertension: How Innovative Packaging Can Improve Patient Outcomes?

Uncontrolled T2D in India: Valuable Consideration for Dapagliflozin Sitagliptin Combination

Uncontrolled T2D in India: Valuable Consideration for Dapagliflozin Sitagliptin Combination

JAPI Releases Dedicated Supplement Addressing Clinical Needs for Adult Vaccination in India

JAPI Releases Dedicated Supplement Addressing Clinical Needs for Adult Vaccination in India

Cuticapil Stem Hair Serum as Add-On to Minoxidil Shows Superior Hair Growth in Androgenetic Alopecia : Indian Real World Data

Cuticapil Stem Hair Serum as Add-On to Minoxidil Shows Superior Hair Growth in Androgenetic Alopecia...

View All

Journal Club Today

Sausages, Sodas, and Cancer: Ultra-Processed Foods May Be Linked to Higher Lung Cancer Risk

Sausages, Sodas, and Cancer: Ultra-Processed Foods May Be Linked to Higher Lung Cancer Risk

View All

Health News Today

Health Bulletin 01/August/ 2025

Health Bulletin 01/August/ 2025

View All
© 2022 All Rights Reserved.
Powered By: Hocalwire
X
We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok