Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Cardiology-CTVS
  • Cardiology & CTVS News
  • Traces of multiple...

Traces of multiple urinary metals play key role in cardiovascular disease and mortality, finds study

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2024-08-03T09:30:23+05:30  |  Updated On 3 Aug 2024 9:30 AM IST
Traces of multiple urinary metals play key role in cardiovascular disease and mortality, finds study
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

Higher levels of urinary metals such as cadmium, tungsten, uranium, cobalt, copper and zinc are linked to increased cardiovascular disease and mortality in a racially and ethnically diverse U.S. population, according to a new study at Columbia University Mailman School of Public Health. While it is well documented that exposure to certain metals has been associated with cardiovascular disease (CVD) and mortality, until now the evidence was limited beyond arsenic, cadmium, and lead and for a racially diverse population. The findings are published in the journal Circulation.

When analyzed together, the 6 metal-mixture including cadmium, tungsten, uranium, copper, cobalt, and zinc was associated with a 29 percent increased risk of cardiovascular disease and a 66% increased risk of death over the study follow up of 18 years. Increased risk of CVD and mortality was also identified for every metal individually.

“Our study presents the results from the largest prospective study of urinary metals and cardiovascular disease to date and supports the role of urinary metals as novel risk factors for CVD and all-cause mortality risk,” said Irene Martinez-Morata, MD, PhD, in the Department of Environmental Health Sciences at Columbia Mailman School, and lead author. “Our findings can inform risk prediction and preventive strategies to improve cardiovascular health by reducing metal exposures across diverse populations.”

Exposure to metals is widespread, The sources and routes of exposure vary, and can be exacerbated by climate change leading to the contamination of air, soil and water, and ultimately the food chain. Higher burden of metal exposures has been documented across population groups such as non-Hispanic Black, Hispanic/Latino, Chinese, and American Indians, and among communities with lower socioeconomic status, revealing that sociopolitical, historical and structural factors, contribute to disparities beyond individual-level factors such as smoking, occupation and diet. “Interventions to reduce metal exposure can particularly benefit these population groups who also suffer a higher burden of CVD mortality” adds Irene Martinez-Morata.

The American Heart Association recently recognized the toxic metals arsenic, cadmium, and lead as associated with some incidence of CVD. However, until now, studies assessing the effects of less studied metals, including biometals such as copper and zinc, and metal mixtures, more likely to mimic real life exposures, have been limited.

Using the Multi-Ethnic Study of Atherosclerosis (MESA), the researchers assessed the association of six urinary metals with CVD events and mortality from six urban and suburban U.S. communities: Baltimore City and Baltimore County, Maryland; Chicago; Forsyth County, North Carolina; Los Angeles County; Northern Manhattan and the Bronx, NYC; and St. Paul, Minnesota, in July 2000-August 2002. Urine samples were analyzed at the Trace Metals Core Laboratory at Columbia University. To assess the joint effect of urinary metals as a mixture the researchers conducted additional analyses using a machine learning approach recently developed at the Department of Biostatistics at Columbia University.

Of the population analyzed, 39 percent were non-Hispanic White, 27 percent non-Hispanic Black, 22 percent Hispanic/Latino, and 12 percent Chinese descent. Over the study follow up period, 1,162 participants developed CVD and 1,844 participants died.

After accounting for established risk factors of CVD like smoking, hypertension or diabetes, the study identified that higher levels of the mixture of cadmium, tungsten, uranium, cobalt, copper, and zinc in the urine were associated with a 29 percent and a 66 percent increased risk of CVD and mortality, respectively, over the study follow up. For individual metals, higher levels of cadmium were associated with up to 25 percent and 68 percent higher risk of CVD and mortality, respectively. Similar associations were identified for all the other metals.

“Exposure to less studied metals such as tungsten and uranium is common in the U.S. and can occur through drinking water, food, air pollution, and indoor dust,” observed Martinez. While some metals, known as biometals, like copper and zinc are needed in little amounts by our body, high levels of these metals in the urine can be harmful. “While this is an ongoing field of study, high levels of essential metals in the urine can indicate an excess in exposure or loss of body reserves of these nutrients, which can occur when the metabolism is starting to malfunction, as it occurs in early stages of cardiovascular disease.”

“Implementing policies and regulations for air pollution, drinking water and food contamination, and consumer products at the federal level, in addition to addressing community and household vulnerability factors, and individual behavioral changes can reduce exposure to metals, and we note that further analyses will help inform prevention strategies and interventions, including those directed at less studied and unregulated metals such as tungsten or cobalt” noted Martinez. “And while federal regulations for lowering maximum contaminant levels for drinking water and banning leaded gasoline, for example, have successfully reduced exposure to toxic metals such as arsenic, cadmium, and lead in water and air, much more study is needed to understand the contributions of such metals as tungsten and cobalt.”

“A strength of our study is how we assessed the association of urine metals as a mixture,” said Ana Navas-Acien, MD, PhD, professor and chair of Columbia Mailman School Department of Environmental Health Sciences. “In addition to sampling a large population size and a racially and diverse participant base, we used state-of-the-art laboratory methods – led by our Trace Metals Core Laboratory, and we analyzed outcomes over a long follow-up. However, future studies using repeated measures of urine metal levels can provide even more advanced information about exposure over time.”

“The findings underscore the importance of reducing environmental exposure to these metals, which have disproportionately affected minority and poorer communities,” says Cashell Jaquish, PhD, a genetic epidemiologist at the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), and a program officer with the MESA study. “The results could lead to efforts to reduce metal exposure in our communities and thereby reduce health disparities in heart disease, the leading cause of death in this country.”

Reference:

Irene Martinez-Morata, Kathrin Schilling, Ronald A. Glabonjat, Melanie Mayer, Katlyn McGraw, Marta Galvez Fernandez, Association of Urinary Metals With Cardiovascular Disease Incidence and All-Cause Mortality in the Multi-Ethnic Study of Atherosclerosis (MESA), Circulation, https://doi.org/10.1161/CIRCULATIONAHA.124.069414.

Circulationcardiovascular diseaseAmerican Heart Association
Source : Circulation
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

Show Full Article
Next Story

Editorial

ABYSS Trial Finds Elevated BP, HR & Deleterious CV Outcomes After Beta blocker Withdrawal Post-MI: EuroPCR 2025 Update

ABYSS Trial Finds Elevated BP, HR & Deleterious CV Outcomes After Beta blocker Withdrawal Post-MI:...

Aspirin Use in Male Smokers Aged 40-45 Years with Hypertension: Identifying the Ideal Candidates

Aspirin Use in Male Smokers Aged 40-45 Years with Hypertension: Identifying the Ideal Candidates

National Consensus 2025 on Role of Bisoprolol Across CV Continuum in Women: Top 10 Takeaways

National Consensus 2025 on Role of Bisoprolol Across CV Continuum in Women: Top 10 Takeaways

Relevance of Pioglitazone in Indian T2DM Care Continuum

Relevance of Pioglitazone in Indian T2DM Care Continuum

Azmarda Outperforms Generic Sacubitril/Valsartan in HFrEF Management, says new study

Azmarda Outperforms Generic Sacubitril/Valsartan in HFrEF Management, says new study

View All

Journal Club Today

Study Unveils Molecular Links between Air Pollution and Negative Birth Outcomes

Study Unveils Molecular Links between Air Pollution and Negative Birth Outcomes

View All

Health News Today

Health Bulletin 05/June/2025

Health Bulletin 05/June/2025

View All
© 2022 All Rights Reserved.
Powered By: Hocalwire
X
We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok