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Underweight Asians may be at increased risk of atrial fibrillation, states research
China: Findings from a recent meta-analysis have suggested an association between being underweight and an increased risk of atrial fibrillation (AF) in the Asia population. The findings were published online in the International Journal of Cardiology Cardiovascular Risk and Prevention on February 17, 2024.
However, the researchers stated, "Whether the results can be generalized to other regions requires further research."
According to the authors, their study is the first meta-analysis to assess the association between the underweight and the risk of atrial fibrillation in the Asia population.
"We found that compared with the normal BMI group, there was an increase in the atrial fibrillation incidence in the underweight group by 31% in the Asia population," the researchers reported. "Dose-response analysis showed per 1 unit BMI decrement increases the AF risk by 6%."
Atrial fibrillation is considered the most common sustained arrhythmia in adults, and its prevalence is expected to rise in the future. It is estimated that the number of people with atrial fibrillation could increase by 2.5 times more than now by 2050. Additionally, individuals in Asia are more likely to be diagnosed with AF than individuals in Europe or the United States.
Multiple risk factors contribute to the incidence of atrial fibrillation, such as left ventricular hypertrophy, advanced age, obesity, myocardial infarction, and alcohol consumption, which is consistent among Asian populations as in Europe and the US populations. However, the prevalence of underweight is lower in Western countries, due to which the relationship between underweight and atrial fibrillation is poorly studied. However, in the Asian population, there is a relatively high prevalence of underweight.
Against the above background, Jing Zhang, The Second Affiliated Hospital of Nanchang University, Nanchang, China, and colleagues aimed to elucidate the relationship between underweight and atrial fibrillation in Asians in a meta-analysis.
For this purpose, they searched three databases for cohort studies on the relationship between underweight and AF risk in Asians. Underweight was defined as body mass index (BMI) < 18.5 kg/m2. Six cohort studies comprising 427,844 patients were included; of those, 27,429 were underweight.
The researchers reported the following findings:
- Underweight has a 30% greater risk of atrial fibrillation compared with normal weight (RR:1.31).
- Dose-response results showed a per 1 unit BMI decrement was associated with the risk of atrial fibrillation by 6% in underweight.
"Based on current evidence, our findings indicate that individuals with underweight may be at increased risk of atrial fibrillation in Asia," the research team concluded.
Reference:
Deng, Y., Tang, X., Fu, W., Ling, Q., Xia, P., Zhao, H., Yu, P., Zhang, J., & Liu, X. (2024). Underweight and the risk of atrial fibrillation in Asian population: A meta-analysis. International Journal of Cardiology Cardiovascular Risk and Prevention, 200245. https://doi.org/10.1016/j.ijcrp.2024.200245
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751