- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Voltage-Guided PVI Matches Conventional Methods in Efficacy and Slashes Procedure Time for AF Treatment: Study
![Voltage-Guided PVI Matches Conventional Methods in Efficacy and Slashes Procedure Time for AF Treatment: Study Voltage-Guided PVI Matches Conventional Methods in Efficacy and Slashes Procedure Time for AF Treatment: Study](https://medicaldialogues.in/h-upload/2022/04/16/750x450_174429-catheter-ablation-for-af.webp)
Japan: Voltage-guided pulmonary vein isolation (PVI) demonstrated comparable efficacy to conventional lesion size index (LSI)-guided PVI in treating patients with atrial fibrillation (AF) while notably shortening the procedure time, a recent study. The findings were published online in Heart Rhythm on August 22, 2024.
Atrial fibrillation, a common cardiac arrhythmia, affects millions worldwide and can lead to severe complications such as stroke and heart failure. The standard treatment for this condition has been catheter ablation, which involves isolating the pulmonary veins to prevent abnormal electrical signals that cause AF. Traditionally, this procedure has been guided by LSI, which maps the electrical activity of the heart to create precise lesions around the pulmonary veins.
However, voltage-guided PVI has emerged as a promising alternative. Unlike LSI-guided methods that focus on creating a specific set of lesions based on electrical activity, voltage-guided PVI utilizes the voltage signals in the heart to direct the ablation process. This technique relies on detecting low-voltage areas that indicate diseased tissue, allowing for targeted ablation of the pulmonary veins.
Against the above background, Jun Kishihara, Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan, and colleagues aimed to investigate whether voltage-guided PVI is noninferior to conventional LSI-guided PVI in patients with nonvalvular AF.
For this purpose, the researchers conducted a multicenter randomized trial over 12 months. The study’s primary efficacy endpoints included recurrence of atrial fibrillation, atrial flutter, and/or atrial tachycardia, with a noninferiority margin established at a hazard ratio of 1.4. For assessing safety, the main endpoint was a composite measure of complications related to the procedure.
The study led to the following findings:
- A total of 370 patients underwent randomization; 189 and 181 were assigned to the voltage (underwent voltage-guided PVI) and control (underwent conventional LSI-guided PVI) groups, respectively.
- The primary efficacy endpoint occurred in 12.0% of patients in the voltage group and 12.9% in the control group (1-year Kaplan–Meier event-free rate estimates, 88.0%, and 87.1%, respectively; hazard ratio, 1.00).
- The primary safety endpoints were 4.8% in the voltage group and 6.6% in the control group.
- PVI time was significantly shorter in the voltage group (35.7 ± 14.5 min versus 39.7 ± 14.7 min).
"Based on the findings, we found voltage-guided PVI to be noninferior to conventional LSI-guided PVI for efficacy in the treatment of patients with AF, and its use significantly reduced procedure time," the researchers concluded.
Reference:
Kishihara, J., Fukaya, H., Yamashita, K., Ono, M., Igawa, W., Saito, J., Takano, M., Ishizue, N., Nakamura, H., Matsuura, G., & Oikawa, J. (2024). Voltage-guided Pulmonary Vein Isolation for Atrial Fibrillation. Heart Rhythm. https://doi.org/10.1016/j.hrthm.2024.08.041
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751