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YETI score, useful tool for predicting recovery after iatrogenic cryoballoon-related PNI: Circulation
Germany: Phrenic nerve injury (PNI) is the most common complication that occurs during cryoballoon-based pulmonary vein isolation (PVI). Now, the latest study published in the journal Circulation: Arrhythmia and Electrophysiology has found that the incidence of PNI during the procedure to be 4.2%. Within 12 months, 97% of PNI recovered.
Further, symptomatic and permanent was shown to be exceedingly rare in patients following cryoballoon-based PVI. Prognosis can be estimated by YETI score after atrogenic cryoballoon-derived PNI, the authors noted.
"YETI score has a numerical value that will directly represent the probability of a specific patient of recovering from PNI within 12 months," Christian-H. Heeger and the team from Germany wrote in their study.
Cryoballoon-based pulmonary vein isolation is an effective treatment for atrial fibrillation. The most frequent complication during cryoballoon-based PVI is phrenic nerve injury. However, there is not much data on PNI.
The YETI registry is a retrospective, multinational, and multicenter registry that evaluates the incidence, characteristics, prognostic factors for PNI recovery, and follow-up data of patients with PNI during cryoballoon-based PVI. It included patients with PNI during CB2 or third (CB3) and fourth-generation cryoballoon (CB4)-based PVI.
A total of 17 356 patients underwent cryoballoon-based PVI in 33 centers from 17 countries.
The study revealed the following findings:
- A total of 731 (4.2%) patients experienced PNI. The mean time to PNI was 127.7±50.4 seconds, and the mean temperature at the time of PNI was −49±8 °C.
- At the end of the procedure, PNI recovered in 394/731 patients (53.9%).
- Recovery of PNI at 12 months of follow-up was found in 97.0% of patients (682/703, with 28 patients lost to follow-up).
- A total of 16/703 (2.3%) reported symptomatic PNI.
- Only 0.06% of the overall population showed symptomatic and permanent PNI.
- Prognostic factors improving PNI recovery are immediate stop at PNI by double-stop technique and utilization of a bonus-freeze protocol.
- Age, cryoballoon temperature at PNI, and compound motor action potential amplitude loss >30% were identified as factors decreasing PNI recovery.
- Based on these parameters, a score was calculated.
- The YETI score has a numerical value that will directly represent the probability of a specific patient recovering from PNI within 12 months.
"We found the incidence of PNI during cryoballoon-based PVI to be 4.2%," wrote the authors. "Overall 97% of patients affected by PNI recovered within 12 months. Symptomatic and permanent PNI is exceedingly rare in patients after cryoballoon-based PVI."
Reference:
The study titled, "Phrenic Nerve Injury During Cryoballoon-Based Pulmonary Vein Isolation: Results of the Worldwide YETI Registry," was published in the journal Circulation: Arrhythmia and Electrophysiology.
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751