Medical Dialogues
  • Dermatology
Sign in Signup
This site is intended for healthcare professionals only
Sign in Signup
  • Medical Jobs
  • Medical Matrimony
  • MD Brand Connect
  • MDTV
Medical Dialogues
  • Medical News
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • MCI News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Medical Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
  • MDTV
      • Anesthesia
      • CTVS
      • Cardiology
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • Diet and nutrition
      • ENT
      • Gastroenterology
      • Health Dialogues
      • Health News today
      • Health Shorts
      • Health Updates
      • Health video of the day
      • Laboratory Medicine
      • Latest Videos
      • Latest Webinars
      • MD shorts
      • Medical News Today
      • Medical Updates
      • Medical Video of the day
      • Medicine
      • Nephrology
      • Neurology and Neurosurgery
      • Obstetrics and Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics & Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Top Videos
      • Urology
This site is intended for healthcare professionals only
Sign InRegister
Medical Dialogues
Sign inRegister
  • Home
  • Medical news
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • MCI News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Medical Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
  • Case of the Day
  • Editorial
  • Home
  • Cardiology-CTVS
  • Cardiology & CTVS Perspective
  • Cardiovascular...

Cardiovascular benefits of ketone diet: just a gimmick or real science?

dr. Abhimanyu UppalBy dr. Abhimanyu UppalPublished On 2021-03-16T11:45:05+05:30  |  Updated On 2021-03-16T14:00:11+05:30
Cardiovascular benefits of ketone diet: just a gimmick or real science?
Cardiovascular benefits of ketone diet: just a gimmick or real science?
Cardiovascular benefits of ketone diet: just a gimmick or real science?

Metabolic perturbations underlie a variety of cardiovascular disease states; yet, metabolic interventions to prevent or treat these disorders are sparse. Ketones carry a negative clinical stigma as they are involved in diabetic ketoacidosis. However, evidence from both experimental and clinical research has uncovered a protective role for ketones in cardiovascular disease. Growing...

Metabolic perturbations underlie a variety of cardiovascular disease states; yet, metabolic interventions to prevent or treat these disorders are sparse. Ketones carry a negative clinical stigma as they are involved in diabetic ketoacidosis. However, evidence from both experimental and clinical research has uncovered a protective role for ketones in cardiovascular disease.

Growing evidence suggests that ketones may be beneficial for patients with cardiovascular disease (CVD). Interventions that enhance circulating ketone levels result in increased myocardial ketone oxidation and improved cardiac function.

In addition to the expected role of ketones as an efficient substrate for (cardiac) metabolism, as they require less oxygen per molecule of ATP generated, ancillary cardioprotective effects of ketone bodies beyond energetics have also recently been identified.

Cardiac diseases are associated with loss of metabolic flexibility. Even in early stages of structural heart diseases, substrate utilization switches from fatty acids to glucose utilization, and oxidative metabolism is reduced. This metabolic reprogramming results in a fuel preference pattern that is similar to the fetal state. The majority of evidence indicates that the reduced capacity to utilize fatty acids sets the stage for myocardial energy starvation, contributing to the pathogenesis of heart failure (HF). Intriguingly, in the context of reduced fatty acid oxidation, the failing heart appears to reprogram metabolism to increased reliance on ketone bodies as a fuel source.

Strategies to induce ketosis relevant to heart failure:

In general, a BHB level ≥0.5 mmol/l has been considered as a cut-off point for entry into ketosis.

Ketosis can also be achieved by a ketogenic diet (KD) or by ingesting ketone precursors, such as 1,3-butanediol or medium-chain triglyceride (MCT). Alternatively, exogenous sources of ketones, such as ketone salts (KS) or ketone esters (KE), can be ingested. The KD has become extremely popular, both within and outside of the medical arena. KD consists of a very low-carbohydrate and high-fat diet that forces the body into endogenous ketosis. Although sustained KD can raise blood βOHB to 2 to 4 mmol/l, long-term compliance is low, often due to gastrointestinal (GI) distress (Figure 1).

SGLT2i induced ketosis and cardiovascular benefits:

Sodium-glucose cotransporter inhibitors (SGLT2i) are drugs that stimulate urinary glucose excretion and have recently received considerable interest because of their cardiovascular benefits in HF patients with and without diabetes. SGLT2i reduce insulin levels and stimulate lipolysis, which in turn drives ketone production in the liver. Accordingly, SGLT2i induce mild ketosis in both diabetic and nondiabetic subjects. Some authors have suggested that CV benefits during SGLT2i are mediated by the increases in circulating ketone bodies.

Ketone Bodies: Pleiotropic Effects Beyond Cardiac Energetics:

Besides the effects of ketones on (cardiac) energetics, several pleiotropic effects of ketones have been identified that may provide additional CV benefit (Figure 2)

Summary:

Evidence for benefits of ketone bodies in subjects with cardiovascular disease is rapidly emerging. In addition to the role of ketones in provision of an ancillary fuel for the failing heart, ketone bodies may also exert a myriad of pleiotropic effects. Ketone bodies may improve endothelial function, ameliorate oxidative stress, improve mitochondrial function, exert anti-inflammatory actions, and mitigate cardiac remodeling. Other systemic extracardiac effects on body weight, blood pressure, glycemia, and lipid profile may also benefit patients with CVD. Regardless of the pathway to achieve ketosis, ketone bodies have potential clinical applications that require further exploration, including new therapeutic approaches to harness the beneficial effect of ketosis. In the coming years, we will learn whether ketone bodies can be beneficial and optimized to be used in treatment and prevention of CVD.

ketone diet Cardiovascular risk 
dr. Abhimanyu Uppal
dr. Abhimanyu Uppal

    Dr Abhimanyu Uppal completed his M. B. B. S and M. D. in internal medicine from the SMS Medical College in Jaipur. He got selected for D. M. Cardiology course in the prestigious G. B. Pant Institute, New Delhi in 2017. After completing his D. M. Degree he continues to work as Post DM senior resident in G. B. pant hospital. He is actively involved in various research activities of the department and has assisted and performed a multitude of cardiac procedures under the guidance of esteemed faculty of this Institute.

    Show Full Article
    Next Story
    Similar Posts
    NO DATA FOUND

    Editorial

    Review: Efficacy of Antiviral Agents Against  Omicron Subvariant BA.2

    Review: Efficacy of Antiviral Agents Against Omicron Subvariant BA.2

    Choice of Antibiotics in Common Infections: Doxycycline or Azithromycin?

    Choice of Antibiotics in Common Infections: Doxycycline or Azithromycin?

    Role of acyclovir in Management of chickenpox: Analyzing the importance of starting early

    Role of acyclovir in Management of chickenpox: Analyzing the importance of starting early

    Parkinsonism and the place of Amantadine - Review Analysis

    Parkinsonism and the place of Amantadine - Review Analysis

    When to Introduce time tested drug Amlodipine to manage Hypertension?

    When to Introduce time tested drug Amlodipine to manage Hypertension?

    View All

    Journal Club Today

    Quitting Smoking After Lung Cancer Diagnosis Worth Doing

    Quitting Smoking After Lung Cancer Diagnosis Worth Doing

    View All

    Health News Today

    Health Bulletin 17/May/2022

    Health Bulletin 17/May/2022

    View All
    © 2019 All Rights Reserved.
    Powered By: Hocalwire
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok
    X
    X