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Improved enteral feeding for first seven days linked to lower 28-day mortality in critically sick patients
Recently published study aimed to assess the association between nutrition intake and 28-day mortality in critically ill patients receiving exclusive enteral nutrition (EN) during the first week of ICU admission and the potential impact of lactate levels on this association. The study was a post hoc analysis of a cluster-randomized clinical trial and included 1322 patients who received exclusive EN during their first week of ICU stay. The findings showed that increased energy and protein delivery during the first week were associated with a significant reduction in 28-day mortality. However, this association was observed only in patients with lactate concentration ≤ 2 mmol/L and not in those with lactate concentration > 2 mmol/L. The study also highlighted that the nutrition therapy provided was suboptimal, with most patients receiving only approximately 50% of their energy and protein requirements.
Findings and Association with Mortality
The study addressed the potential impact of using ideal body weight instead of actual body weight and found that the results remained stable in different models. The authors acknowledged limitations of the study, such as the post hoc nature, differences in patient populations, and the inability to weigh the importance of energy and protein delivery due to multicollinearity. The study concluded that enhanced nutrition delivery was associated with reduced 28-day mortality in critically ill patients receiving exclusive EN during the first week of ICU admission, particularly in patients with lactate concentration ≤ 2 mmol/L. The findings suggest that further prospective studies are needed to confirm these results and address the limitations identified in this study.
Reference
Chen, Y., Liu, Z., Wang, Q. et al. Enhanced exclusive enteral nutrition delivery during the first 7 days is associated with decreased 28-day mortality in critically ill patients with normal lactate level: a post hoc analysis of a multicenter randomized trial. Crit Care 28, 26 (2024). https://doi.org/10.1186/s13054-024-04813-6.
MBBS, MD (Anaesthesiology), FNB (Cardiac Anaesthesiology)
Dr Monish Raut is a practicing Cardiac Anesthesiologist. He completed his MBBS at Government Medical College, Nagpur, and pursued his MD in Anesthesiology at BJ Medical College, Pune. Further specializing in Cardiac Anesthesiology, Dr Raut earned his FNB in Cardiac Anesthesiology from Sir Ganga Ram Hospital, Delhi.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751