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  • 3-day Systemic...

3-day Systemic Antibiotics with Subgingival Instrumentation good enough for aggressive Periodontitis

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-07-10T21:48:54+05:30  |  Updated On 10 July 2022 9:48 PM IST
3-day Systemic Antibiotics with Subgingival Instrumentation good enough for aggressive Periodontitis
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Recent research found that in aggressive periodontitis patients a 3-day systemic administration of Amoxicillin and Metronidazole along with subgingival instrumentation yielded good clinical outcomes after 6 months with fewer adverse events. The study was published in "Journal of Clinical Periodontology."

Periodontitis can cause severe functional and esthetic dysfunctions. It is a multifactorial disease caused due to disturbances in angiogenesis, microbiota, and inflammatory infiltrate. Instrumentation and antibiotics are the mainstays of treatment of periodontitis. Raluca et al conducted a study to evaluate the clinical non-inferiority of a 3-day-protocol of systemic antibiotics (SAB) adjunctive to subgingival instrumentation (SI) compared to a 7-day-protocol in patients with stage III/IV grade C periodontitis.

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A randomized study was performed on 50 systemically healthy patients aged 32.7±4.3 years with aggressive periodontitis (stage III/IV grade C periodontitis). Subgingival Instrumentation along with adjunctive antibiotics (AB) like amoxicillin and metronidazole were given. Patients were assigned to two groups of 25 each randomly. Group A was given 500mg antibiotics 3-times-daily for 3 days, followed by a placebo 3-times-daily for 4 days, and group B was given 500mg antibiotics 3-times-daily for 7 days. Clinical, microbial, and immunological parameters were assessed at baseline, 3 and 6 months, and patient-related outcomes after 2 weeks. The number of residual sites with PD≥6mm at 6 months was the primary outcome variable.

Results:

  • For the primary outcome variable, the null hypothesis was rejected and demonstrated the non-inferiority of the 3d AB protocol compared to 7d AB.
  • Comparable clinical improvements were obtained for all parameters with both antibiotic protocols (p>0.05).
  • Significant reduction of all investigated periodontopathogens and pro-inflammatory host-derived markers were observed, without differences between the treatments (p>0.05).
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Thus, researchers concluded that in patients with aggressive periodontitis (stage III/IV grade C periodontitis), the clinical outcomes of a 3-day administration of systemic amoxicillin and metronidazole adjunctive to SI were non-inferior to a 7-day-protocol after 6-months.

To read the full article, click here: https://doi.org/10.1111/jcpe.13676

Cosgarea R, Jepsen S, Heumann C, et al. Clinical, microbiological and immunological effects of 3- or 7-day systemic antibiotics adjunctive to subgingival instrumentation in patients with aggressive (stage III/IV grade C) periodontitis: a randomized placebo-controlled clinical trial [published online ahead of print, 2022 Jul 4]. J Clin Periodontol. 2022;10.1111/jcpe.13676.

Systemic antibioticsAggressive PeriodontitisSubgingival Instrumentationperiodontitis
Source : Journal of Clinical Periodontology
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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