- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
3-day Systemic Antibiotics with Subgingival Instrumentation good enough for aggressive Periodontitis
Recent research found that in aggressive periodontitis patients a 3-day systemic administration of Amoxicillin and Metronidazole along with subgingival instrumentation yielded good clinical outcomes after 6 months with fewer adverse events. The study was published in "Journal of Clinical Periodontology."
Periodontitis can cause severe functional and esthetic dysfunctions. It is a multifactorial disease caused due to disturbances in angiogenesis, microbiota, and inflammatory infiltrate. Instrumentation and antibiotics are the mainstays of treatment of periodontitis. Raluca et al conducted a study to evaluate the clinical non-inferiority of a 3-day-protocol of systemic antibiotics (SAB) adjunctive to subgingival instrumentation (SI) compared to a 7-day-protocol in patients with stage III/IV grade C periodontitis.
A randomized study was performed on 50 systemically healthy patients aged 32.7±4.3 years with aggressive periodontitis (stage III/IV grade C periodontitis). Subgingival Instrumentation along with adjunctive antibiotics (AB) like amoxicillin and metronidazole were given. Patients were assigned to two groups of 25 each randomly. Group A was given 500mg antibiotics 3-times-daily for 3 days, followed by a placebo 3-times-daily for 4 days, and group B was given 500mg antibiotics 3-times-daily for 7 days. Clinical, microbial, and immunological parameters were assessed at baseline, 3 and 6 months, and patient-related outcomes after 2 weeks. The number of residual sites with PD≥6mm at 6 months was the primary outcome variable.
Results:
- For the primary outcome variable, the null hypothesis was rejected and demonstrated the non-inferiority of the 3d AB protocol compared to 7d AB.
- Comparable clinical improvements were obtained for all parameters with both antibiotic protocols (p>0.05).
- Significant reduction of all investigated periodontopathogens and pro-inflammatory host-derived markers were observed, without differences between the treatments (p>0.05).
Thus, researchers concluded that in patients with aggressive periodontitis (stage III/IV grade C periodontitis), the clinical outcomes of a 3-day administration of systemic amoxicillin and metronidazole adjunctive to SI were non-inferior to a 7-day-protocol after 6-months.
To read the full article, click here: https://doi.org/10.1111/jcpe.13676
Cosgarea R, Jepsen S, Heumann C, et al. Clinical, microbiological and immunological effects of 3- or 7-day systemic antibiotics adjunctive to subgingival instrumentation in patients with aggressive (stage III/IV grade C) periodontitis: a randomized placebo-controlled clinical trial [published online ahead of print, 2022 Jul 4]. J Clin Periodontol. 2022;10.1111/jcpe.13676.
BDS, MDS
Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751