Altered Bone turnover markers levels linked to progressive deterioration of the periodontium
Previous studies have not been conclusive regarding the association between bone turnover markers (BTMs) and periodontitis.
Association between bone turnover markers and periodontitis cannot be confirmed according to a recent study published in the Journal of Clinical Periodontology.
The clinical implications of the study are that altered serum BTM levels may be associated with progressive deterioration of the periodontium. However, the markers most commonly used appear unsuitable in a cross-sectional context.
A study was conducted to examine the associations between bone turnover markers and periodontitis in two cross-sectional population-based studies.
They used data from two independent adult samples (N = 4993), collected within the Study of Health in Pomerania project, to analyse cross-sectional associations of N-procollagen type 1 amino-terminal propeptide (P1NP), C-terminal cross-linking telopeptide, osteocalcin, bone-specific alkaline phosphatase (BAP), fibroblast growth factor 23, wingless-type mouse mammary tumour virus integration site family member 5a (WNT5A), and sclerostin values with periodontitis. Confounder-adjusted gamma and fractional response regression models were applied.
Results
- Positive associations were found for P1NP with mean pocket probing depth, mean clinical attachment loss, and proportion of sites with bleeding on.
- Similar associations were seen for BAP with %BOP, proportion of sites with PPD ≥4 mm (%PPD4), and sclerostin with %BOP.
- WNT5A was inversely associated with mean PPD and %PPD4
The researchers found scattered associations of periodontitis markers with N-procollagen type 1 amino-terminal propeptide, bone-specific alkaline phosphatase, wingless-type mouse mammal tumour virus integration site family member 5a, and sclerostin. However, the most commonly used marker for bone resorption (C-terminal cross-linking telopeptide) did not reveal any association.
This study revealed scattered associations of P1NP, BAP, WNT5A, and sclerostin with periodontitis, but the results are contradictory in the overall context. Associations reported in previous studies could not be confirmed.
Reference:
Reckelkamm, S. L., Hannemann, A., Kocher, T., Nauck, M., Völzke, H., Ehmke, B., Rauner, M., Alayash, Z., Baumeister, S.-E., Nolde, M., & Holtfreter, B. (2022). Association between bone turnover markers and periodontitis: A population-based cross-sectional study. Journal of Clinical Periodontology, 49( 7), 633– 641.https://doi.org/10.1111/jcpe.13649
