Arginine metabolites linked to smoking related periodontitis

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-12-05T20:00:00+05:30 | Updated On 5 Dec 2022 8:00 PM IST

Researchers have found in a new study that arginine metabolites are linked to smoking related periodontitis.

The study conducted by Melis Yilmaz and team showed that Periodontitis due to smoking and salivary levels of ADMA (asymmetric dimethylarginine) and SDMA (symmetric dimethylarginine) were associated.

The findings of this study were published in Oral Diseases.

The term "periodontitis" refers to a group of inflammatory disorders that can damage the periodontium, the structure that supports teeth, as well as the gingivae, alveolar bone, cementum, and periodontal ligament. Periodontal disease can cause tooth loss and contribute to systemic inflammation. Any type of tobacco usage increases the chance of getting more serious periodontal disease. Numerous studies have demonstrated that smokers' results from non-surgical and surgical periodontal therapy are inferior to those of non-smokers. Cigarette use is widespread throughout the world, and in addition to its detrimental impacts on health, its effects on periodontitis are notable. Cardiovascular disorders are among the systemic inflammatory diseases that are influenced by arginine metabolites. As a result, the goal of this study was to compare the levels of IL-6 and arginine metabolites in healthy and periodontitis patients' serum and saliva based on their smoking status.

There were four groups in the study: healthy people (control; n=20), smokers with healthy periodontium; nonsmokers with Stage-III Grade-B generalized periodontitis; and smokers with Stage-III Grade-C generalized periodontitis; n=18. We measured periodontal parameters. ELISA kits were used to measure the amounts of IL-6, while LC-MS/MS was used to analyze the metabolites of methylated arginine.

The key findings of this study were:

1. Salivary levels of ADMA and SDMA were higher in the periodontitis group in nonsmokers than in the control group (p 0.001, p = 0.010).

2. Smokers with periodontitis had higher saliva concentrations of arginine (p = 0.030, p = 0.001) and ADMA (p = 0.033, p 0.001) compared to smokers and non-smokers.

In conclusion, the results of this study clearly states that smoking raised the blood levels of ADMA, SDMA, and L-NMMA exclusively in those with periodontitis.

Reference:

Yilmaz, M., Yay, E., Atalay, N., Balci, N., Kurgan, Ş., Toygar, H., & Serdar, M. A. (2022). Do Arginine Metabolites Have a Role in Periodontitis Due to Smoking? A New Perspective. In Oral Diseases. Wiley. https://doi.org/10.1111/odi.14448

periodontitisdimethylarginineORAL DISEASESOral Healthsmoking

Source : Oral Diseases

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751