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Bisphenol A from Composite Fillings doesn't alter Reproductive Hormone Levels in Men: Study
Bisphenol A released from composite fillings has no significant effect on reproductive hormone levels in men suggests a study published in the International Dental Journal.
Composite resins are the most preferred filling material because of their excellent aesthetic qualities. However, a filling material should also be biocompatible as well as aesthetic.
A group of researchers from Turkey conducted a study to determine the serum and saliva bisphenol-A (BPA) levels and examine the effects of serum Bisphenol A on reproductive hormone levels after healthy men were treated with composite fillings.
Eighteen healthy males each received 2 composite restorations. Saliva and blood samples of subjects were collected before resin application and 1 day and 1, 3, and 5 weeks after the resin was applied. BPA amounts in samples were detected using high-performance liquid chromatography (HPLC). Serum gonadotropins, testosterone, sex hormone-binding globulin, free androgen index, and oestrogen levels were measured with radioimmunological assay kits. Statistical analysis of data was made using Friedman, Wilcoxon signed ranks and Mann-Whitney U tests.
The results of the study are as follows:
· The amount of Bisphenol A released from composite resins, overtime was not significantly elevated in either saliva or serum.
· In addition, serum Bisphenol A levels were significantly higher than saliva BPA levels for both composites, but saliva and serum Bisphenol A levels were not statistically different when comparing the 2 composites.
Thus, the researchers concluded that Bisphenol A from composite resins used in this study did not significantly alter serum hormone levels.
Reference:
Effects of Bisphenol A Released From Composite Fillings on Reproductive Hormone Levels in Men by Gul P et. al published in the International Dental Journal.
https://doi.org/10.1016/j.identj.2020.12.008
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751