Daily use of lozenge containing arginine and probiotics may benefit children with dental caries

Results

The study was completed by 288 children. The dropout rate was 15%. The increase in ∆mean dICDAS3–6msf-s and ∆mean d/DICDAS3–6m/M-s/S-f/F-s/S was lower in the intervention group (p = 0.007). No differences were found for gingivitis- and plaque occurrence. No product-related side effects were reported. This study followed ICH-GCP including external monitoring.

Daily consumption of a lozenge containing prebiotic arginine and two strains of probiotics showed safe use and statistically significantly reduction in caries incrementbut no effect on the mean plaque or gingivitis occurrence in children. The use of a lozenge with arginine and probiotics combined has a promising potential as a supplementary tool for future management of caries.

The combination of prebiotic arginine and probiotics shows clinical potential as a supplementary approach to toothbrushing with fluoride toothpaste in managing caries increment in children. A new era in the management of caries may be emerging.

Keywords: Randomized clinical trial; Caries; Probiotics; Arginine; Synbiotic; Pediatric dentistry

Reference:

Camilla Juhl Pørksen, Mette Kirstine Keller, Anders Damholt, Amalie Kruse Sigersted Frederiksen, Kim Rud Ekstrand, Merete Markvart, Tove Larsen, Azam Bakhshandeh,

The effect of a lozenge combining prebiotic arginine and probiotics on caries increment in children during 10–12 months, a randomized clinical trial, Journal of Dentistry, Volume 135,

2023, 104599, ISSN 0300-5712. https://doi.org/10.1016/j.jdent.2023.104599.

Keywords:

Daily, use, lozenge, containing, arginine, probiotics, may, benefit, children, with, dental, caries, Camilla Juhl Pørksen, Mette Kirstine Keller, Anders Damholt, Amalie Kruse Sigersted Frederiksen, Kim Rud Ekstrand, Merete Markvart, Tove Larsen, Azam Bakhshandeh, Journal of Dentistry