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Increased release of Bisphenol- A from resin composites tied to toxicity: Study
Increased release of Bisphenol- A (BPA) released from resin composites is associated with local and systemic toxicity, suggests a study published in the Journal of Biomedical Materials Research: Part B.
A group of researchers from Portugal conducted a study to perform an integrative review on the release of bisphenol A (BPA) from resin-matrix composites and potential toxic effects.
A bibliographic search was performed by the researchers on the PubMed platform using the following keywords: "Bisphenol A" OR "BPA" AND "resin composite" OR "composite resin" AND "toxicity" OR "cytotoxicity" OR "release". Inclusion criteria involved in vitro and in vivo studies on the release and toxicity of BPA.
The results of the study are as follows:
· The release of BPA from resin-matrix composites due to insufficient polymerization and/or degradation of the polymeric matrix.
· BPA is part of the organic matrix of resin-matrix composites and may be hydrolysed in human saliva, although studies report that low doses might not be detected by traditional chemical analysis.
· Studies exposing zebrafish embryos to different concentrations of Bis-GMA, showed 55% mortality at 10 μM Bis-GMA while 30% mortality was recorded at 1 μM Bis-GMA.
· In patients, a BPA concentration of around 2.09 × 10−2 μg/ml was found in the saliva after placement of lingual orthodontic retainers with resin-matrix composites.
· Also, the BPA molecule can be swallowed and absorbed by the oral/gastrointestinal mucosa, which might result in systemic toxicity.
· The degradation of resin-matrix composites and release of BPA in an oral environment is dependent on the organic matrix content and on the polymerization method.
Thus, the researchers concluded that increased release of BPA can lead to the absorption into oral and gastrointestinal mucosa with high risks of local and systemic toxicity.
Reference:
An integrative review on the toxicity of Bisphenol A (BPA) released from resin composites used in dentistry by Rocha L et. al published in the Journal of Biomedical Materials Research: Part B.
https://doi.org/10.1002/jbm.b.34843
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751