- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Irisin promotes odontogenic differentiation and angiogenesis in dental pulp cells: Study
![Irisin promotes odontogenic differentiation and angiogenesis in dental pulp cells: Study Irisin promotes odontogenic differentiation and angiogenesis in dental pulp cells: Study](https://medicaldialogues.in/h-upload/2021/09/27/750x450_161056-istockphoto-1165393112-612x612.webp)
Irisin promotes odontogenic differentiation and mineralization as well as has the potential for angiogenesis, suggests a study published in the International Endodontic Journal.
A group of researchers from Korea conducted a study to determine whether irisin, a newly discovered myokine that links exercise-induced and metabolic homeostasis, is able to promote odontogenic differentiation and angiogenesis in human dental pulp cells (HDPCs).
Cell viability in the presence of irisin was measured. Real-time PCR and Western blot analysis were performed to evaluate the expression levels of irisin, odontogenic and angiogenic markers. The involvement of mitogen-activated protein kinase (MAPK) and the protein kinase B (Akt) signalling pathway was evaluated by Western blot. To evaluate mineralization nodule formation, alkaline phosphatase (ALP) staining and alizarin red S staining was performed. Scratch wound assays were performed to evaluate the effects of irisin on cell migration. The data were analysed using a one-way analysis of variance (ANOVA) followed by Tukey post hoc test and Student's t-test.
The results of the study are as follows:
· Irisin significantly promoted odontogenic differentiation as evidenced by the formation of mineralized nodules, induction of ALP activity and upregulation of odontogenic and angiogenic markers.
· Scratch wound assays revealed that irisin significantly increased migration of HDPCs.
· Phosphorylation of both MAPK and Akt was increased by irisin.
· MAPK and Akt inhibitors inhibited mineralization, cell migration and the increased expression of odontogenic and angiogenic markers.
Thus, the researchers concluded that irisin promoted odontogenic differentiation and mineralization and has the potential for angiogenesis through activation of the MAPK and Akt signalling pathways in HDPCs.
Reference:
Irisin promotes odontogenic differentiation and angiogenic potential in human dental pulp cells by Son J et. al published in the International Endodontic Journal.
https://doi.org/10.1111/iej.13435
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751