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Orofacial Mycoses associated with COVID-19
![Orofacial Mycoses associated with COVID-19 Orofacial Mycoses associated with COVID-19](https://medicaldialogues.in/h-upload/2022/10/15/750x450_188118-download-1.webp)
SARS-CoV-2 infection-related immunosuppression, steroid therapy, as well as comorbidities such as diabetic hyperglycemia appear to be the major predisposing factors for the onset of oral and maxillofacial mycoses in patients with COVID-19 across all age groups according to a recent study published in the International Dental Journal
Studies reviewing orofacial mycoses in coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection are sparse. Here they review the major oral and maxillofacial mycoses of COVID-19, the associated comorbidities, and the probable precipitating factors.
English-language manuscripts published between March 2020 and October 2021 were searched using PubMed, OVID, SCOPUS, and Web of Science databases, using appropriate keywords.
The results:
- They identified 30 articles across 14 countries, which met the inclusion criteria of PRISMA guidelines.
- These yielded a total of 292 patients with laboratory-confirmed COVID-19, 51.4% (n = 150) of whom presented with oral and maxillofacial fungal infections, mainly comprising candidosis, mucormycosis, and aspergillosis.
- Candida infections were the most prevalent, present in 64% (n = 96), followed by mucormycosis, and only a single case of aspergillosis was noted. Oral and maxillofacial mycoses were predominantly seen in those with comorbidities, especially in those with diabetes (52.4%). Oral mucormycosis was noted in 8.6% (n = 13) and mainly manifested on the hard palate.
- An overall event rate of oral/maxillofacial mucormycosis manifestation in patients with COVID-19 with diabetes mellitus type 1/2 was about 94% (49/52; 95% confidence interval, 0.73%-0.89%), implying a very high association between diabetes mellitus and the latter condition.
- All fungal infections appeared either concurrently with COVID-19 symptoms or during the immediate recovery period.
Thus, SARS-CoV-2 infection–related immunosuppression, steroid therapy, as well as comorbidities such as diabetic hyperglycemia appear to be the major predisposing factors for the onset of oral and maxillofacial mycoses in patients with COVID-19 across all age groups.
Reference:
Lakshman P. Samaranayake, Kausar S. Fakhruddin, Hien C. Ngo, H.M.N.M. Bandara, Y.Y. Leung, Orofacial Mycoses in Coronavirus Disease-2019 (COVID-19): A Systematic Review, International Dental Journal, Volume 72, Issue 5, 2022, Pages 607-620, ISSN 0020-6539, https://doi.org/10.1016/j.identj.2022.02.010.
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751