Platelet-rich fibrin derivatives help reduce pain after mandibular 3rd molar extraction: Study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-09-13T09:00:00+05:30 | Updated On 13 Sept 2021 9:00 AM IST

Platelet-rich fibrin (PRF) derivatives can only reduce but were unable to prevent postoperative sequelae after mandibular Third molar extraction suggests a study published in the Journal of Oral and Maxillofacial Surgery.

Leukocyte- and platelet-rich fibrin (L-PRF) and advanced-platelet-rich fibrin (A-PRF) that are derivatives of PRF (platelet-rich fibrin) accelerate wound healing and reduce postoperative sequelae after tooth extraction.

This network meta-analysis was conducted by a group of researchers from China who aimed to investigate the effectiveness of L-PRF and A-PRF in mandibular third molar extraction and provide suggestions for alleviating postoperative symptoms and signs.

A comprehensive search of the literature was conducted in PubMed, Embase, Web of Science, and SinoMed databases up to Oct 9, 2020. Three types of randomized controlled trials were included to investigate the effects of PRF derivatives after extracting mandibular third molars: A-PRF and L-PRF groups; A-PRF and control groups; L-PRF and control groups. Their relative effectiveness and ranking were assessed using network meta-analysis and the surface under the cumulative ranking curve (SUCRA) with STATA 16.0 and Revman 5.3, respectively.

The results of the study are as follows:

· Ten randomized controlled trials were included, with 307 mandibular third molar extraction patients involved.

· The results showed that A-PRF had the best effect among the 3 groups in improving postoperative pain on the third and seventh days.

· L-PRF promoted soft tissue healing on the seventh day compared with the control.

· However, other comparisons showed no significant differences.

The researchers concluded that the limited results confirmed that Platelet-rich fibrin (PRF) derivatives only reduced some postoperative symptoms and did not prevent them all. Application of A-PRF after third molar extraction reduced postoperative pain, and L-PRF improved the degree of soft tissue healing.

Reference:

A study titled, "Application of Platelet-Rich Fibrin Derivatives for Mandibular Third Molar Extraction Related Post-Operative Sequelae: A Systematic Review and Network Meta-Analysis" by Bao M et. al published in the Journal of Oral and Maxillofacial Surgery.

DOI: 10.1016/j.joms.2021.07.006

journal of oral and maxillofacial surgeryplatelet-rich fibrin derivativesmandibular third molar

Source : journal of oral and maxillofacial surgery

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751