What is the Potential Role of Injectable Platelet-Rich Fibrin in Dentistry?
Researchers have found in a new research that injectable Platelet-Rich Fibrin (i-PRF) may have a significant role in dentistry, potentially enhancing both soft and hard tissue regeneration. This study was conducted by Unnati S. and colleagues published in the journal JMIR Research Protocols. i-PRF increases the levels of collagen, transforming growth factor β (TGF-β), and PDGF, which makes it a bioactive agent capable of regenerating soft and hard periodontal tissues.
The researchers will search electronically through six major databases: PubMed, Cochrane Library, Google Scholar, Semantic Scholar, Scopus, and Web of Science. Inclusion criteria include only RCTs published in English, which compare i-PRF with other biomaterials for periodontal regeneration. Manual searches will also be carried out through the relevant references. Study selection, data extraction, and risk assessment will be done independently by two reviewers using the Risk of Bias 2 tool.
Key Findings
Databases: A comprehensive database search will be conducted for the research.
Outcomes of Interest: The criteria for evaluation involve mean differences in clinical measures including:
• Gingival Recession: Changes after treatment.
• Probing Pocket Depth: Change following intervention.
• Clinical Attachment Level: Restoration of periodontal structures.
• Bone Gain: Increase in bone density at the affected areas.
• Gingival Width: Soft tissue regeneration results.
• Timeframe: The synthesis started in October 2023 and will end by December 2025.
• Statistical Model: The combined effect sizes and 95% CIs will be estimated using a random-effects model.
The planned systematic review will assess clinical measures to determine i-PRF's place in routine periodontal treatment. i-PRF could revolutionize periodontal therapy by enhancing soft and hard tissue regeneration. This study aims to provide robust evidence for its clinical application, paving the way for improved patient outcomes in dentistry.
Reference:
Shirbhate U, Bajaj P, Wanjari M, Patil M. Role of Injectable Platelet-Rich Fibrin in the Management of Soft and Hard Tissue Periodontal Regeneration in Dentistry: Protocol for a Systematic Review. JMIR Res Protoc. 2025 Jan 23;14:e65137. doi: 10.2196/65137. PMID: 39847766.
