Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • Medical Jobs
  • Medical Matrimony
  • MD Brand Connect
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • MCI News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Aborad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • MCI News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Dermatology
  • Dermatology Cases
  • Favipravir induced...

Favipravir induced Acute generalized exanthematous pustulosis: 1st case reported

Dr Manoj Kumar NayakWritten by Dr Manoj Kumar Nayak Published On 2021-08-28T09:00:14+05:30  |  Updated On 2021-08-28T09:00:35+05:30
Favipravir induced Acute generalized exanthematous pustulosis: 1st case reported

Acute generalized exanthematous pustulosis (AGEP) post favipravir for COVID-19: 1st case reported Favipravir is a synthetic prodrug initially used against influenza A and B viruses. It has now come into focus due to its use against SARS-COV2 virus. Cutaneous adverse events to this drug are rare with pruritus and eczema being the major adverse effects. AGEP has been reported in...

Acute generalized exanthematous pustulosis (AGEP) post favipravir for COVID-19: 1st case reported

Favipravir is a synthetic prodrug initially used against influenza A and B viruses. It has now come into focus due to its use against SARS-COV2 virus. Cutaneous adverse events to this drug are rare with pruritus and eczema being the major adverse effects. AGEP has been reported in COVID-19 patients mostly due to hydroxychloroquine and β-lactam antibiotics. First case report of AGEP secondary to favipiravir was reported in the Journal of Cosmetic Dermatology.

A 20-year-old male was admitted for fever and rapid onset, mildly itchy erythematous, edematous plaques involving the trunks and proximal extremities with grouped pustular lesions on an edematous-erythematous background. Patient was diagnosed with COVID-19 infection 16 days back and favipiravir monotherapy was administered with a loading dose of 1600 mg bid, followed by 600 mg bid daily for 7 days with complete resolution of symptoms. Patient had not taken any drugs other than favipiravir in the last 8 weeks.

Laboratory tests showed neutrophilic leukocytosis (white blood cell count: 20 390/mm3, neutrophil count: 16 620/mm3). Blood, urine and pustule cultures were negative for bacteria. Histologic examination from the abdominal lesions showed acanthosis of the epidermis with numerous neutrophilic subcorneal/intracorneal spongiotic pustules with papillary dermal edema. Dermis showed mixed inflammatory infiltrate composed of lymphocytes, neutrophils, and rare eosinophils. Based on findings patient was diagnosed with favipiravir-induced AGEP, and 1 mg/kg/day systemic prednisolone treatment was initiated. The lesions resolved with desquamation after 7 days of treatment.

This case presented with AGEP 16 days after treatment which was a longer latency period compared to AGEP reported in COVID-19 infected patients in the recent literature. It was hypothesized by the authors that combination of favipiravir and genetic disposition with COVID-19 induced cytokine storm led to delayed development of AGEP in the case reported

Thus this report emphasizes an unreported possible side effect of favipravir, a new agent which has become widely used during pandemic and dermatologists ad physicians should keep this agent as a causative factor for AGEP when dealing with skin findings.

Source- Atak MF, Farabi B, Akbayrak A, KalelioÄŸlu MB, Rao BK. Acute generalized exanthematous pustulosis following treatment with favipiravir in a patient with COVID-19 without hydroxychloroquine use: Report of the first case. J Cosmet Dermatol. 2021 Aug;20(8):2387-2389. doi: 10.1111/jocd.14304. Epub 2021 Jun 27. PMID: 34139069.


COVID-19 AGEP favipravir JCOD 
Source : Journal of Cosmetic Dermatology
Dr Manoj Kumar Nayak
Dr Manoj Kumar Nayak

    MBBS

    Dr Manoj Kumar Nayak has completed his M.B.B.S. from the prestigious institute Bangalore medical college and research institute, Bengaluru. He completed his M.D. Dermatology from AIIMS Rishikesh. He is actively involved in the field of dermatology with special interests in vitiligo, immunobullous disorders, psoriasis and procedural dermatology. His continued interest in academics and recent developments serves as an inspiration to work with medical dialogues.He can be contacted at editorial@medicaldialogues.in.

    Show Full Article
    Next Story
    Similar Posts
    NO DATA FOUND

    Editorial

    Journal Club Today

    Health News Today

    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    X
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok