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  • Chronic Low Sleep...

Chronic Low Sleep Deprivation may increase risk of SLE, finds study

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-30T19:30:07+05:30  |  Updated On 30 Sept 2022 7:30 PM IST
Chronic Low Sleep Deprivation may increase risk of SLE, finds study
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The latest research revealed that Chronic low sleep duration was associated with an increased risk of developing Systemic Lupus Erythematosus. The effect is stronger among those with bodily pain and depression. The study was published in the journal Arthritis Care & Research.

Systemic Lupus Erythematosus is an autoimmune disease where the immune system attacks its tissues. The risk of developing autoimmune diseases has been linked to Sleep deprivation. So, researchers conducted a study to find out if sleep deprivation was associated with the risk of developing SLE using the Nurses' Health Study (NHS) (1986-2016) and NHSII (1989-2017) cohorts.

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Average sleep duration in a 24-hour period was reported in the NHS (1986-2014) and NHSII (1989-2009). Using biennial questionnaires information on Lifestyle, exposure, and medical information was collected. The association between cumulative average sleep duration (categorical variables) and incident SLE was analyzed by the Adjusted Cox regression analyses model. Interactions between sleep duration and shiftwork, bodily pain (Short-Form 36 questionnaire, SF-36), and depression were examined.

Results

  • 186,072 women with 187 incident SLE cases during 4,246,094 person-years of follow-up were included.
  • Chronic low sleep duration which is ≤5 hours/night vs reference >7-8 hours was associated with increased SLE risk, which persisted after the analysis was lagged and adjusted for shiftwork, bodily pain, and depression.
  • additive interactions between low sleep duration and high bodily pain (SF-36 <75) with an attributable proportion (AP) of 64% and an HR for SLE of 2.97 for those with both risk factors compared to those with neither.
  • Similarly, there was an interaction between low sleep duration and depression with an AP of 68% and an HR for SLE of 2.82.
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Thus, the researchers highlighted the potential role of adequate sleep for disease prevention and found that chronic low sleep duration was associated with higher SLE risk, and they also added that the effect was stronger among those with bodily pain and depression.

To read the full article, click here: https://doi.org/10.1002/acr.25017

Choi MY, Malspeis S, Sparks JA, Cui J, Yoshida K, Costenbader KH. Association of Sleep Deprivation and the Risk of Developing Systemic Lupus Erythematosus among Women [published online ahead of print, 2022 Sep 12]. Arthritis Care Res (Hoboken). 2022;10.1002/acr.25017.

Sleep deprivationautoimmune diseasesSystemic Lupus ErythematosusSLE riskbodily paindepressionChronic low sleep duration
Source : Arthritis Care & Research
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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