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Combination 5-FU/Calcipotriene Cream Shows Promise in Treating Cutaneous Squamous Cell Carcinoma: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-09-30T21:45:16+05:30  |  Updated On 1 Oct 2024 12:13 PM IST
Combination 5-FU/Calcipotriene Cream Shows Promise in Treating Cutaneous Squamous Cell Carcinoma: Study
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USA: A recent pilot study, published in the Journal of the American Academy of Dermatology has shown that a combination topical cream containing 5% 5-fluorouracil and 0.005% calcipotriene is significantly more effective in treating cutaneous squamous cell carcinoma in situ (SCC) than a placebo. This innovative treatment approach could offer new hope for patients facing this common form of skin cancer.

5-fluorouracil (5-FU) is a well-established chemotherapeutic agent commonly used for various types of skin cancer due to its ability to inhibit cellular proliferation. Calcipotriene, a synthetic derivative of vitamin D3, is known for regulating skin cell growth and differentiation. The synergistic effect of these two agents in a topical formulation offers a novel therapeutic strategy for addressing cutaneous malignancies.

Currently, there are no Food and Drug Administration (FDA)-approved topical treatments specifically for squamous carcinoma in situ. Given that the combination of topical 5-FU and calcipotriene is effective for treating actinic keratoses, Riya T. Patel, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, and colleagues investigated its potential application for SCCIS.

This randomized single-blinded study evaluated the outcomes in 24 patients with biopsy-confirmed squamous cell carcinoma in situ. Participants were treated with either a placebo cream applied twice daily or cream containing 5-fluorouracil 5.0% and calcipotriene 0.005%, also applied twice daily, for 7 or 14 days.

The study led to the following findings:

  • After tumor excision, the proportion of patients with histological clearance was significantly higher in the 7-day (83.3%) and 14-day (87.5%) treatment groups than in the placebo group.
  • Two patients receiving treatment developed eruptive squamous atypia within the scar 2 to 3 months after excision, whereas none of those receiving placebo experienced any adverse events.

Overall, the pilot study presents encouraging evidence for using a combination of topical 5-fluorouracil and calcipotriene in treating cutaneous SCC in situ. As further research is conducted, this innovative approach could lead to more effective and safer treatment options for patients, ultimately improving outcomes in managing skin cancer. The findings underscore the need for continued exploration of combination therapies in dermatologic oncology.

Reference:

Patel, R. T., Fagan, K. K., Quan, E. Y., Johnson, N. M., Tegge, A. N., Holliday, A. C., Grider, D. J., Rush, P. S., Prickett, K. A., Eikenberg, J. D., & Phillips, M. A. (2024). Combination topical 5-fluorouracil 5%/calcipotriene 0.005% cream for the treatment of cutaneous in situ squamous cell carcinoma: A pilot study. Journal of the American Academy of Dermatology. https://doi.org/10.1016/j.jaad.2024.08.039


Journal of the American Academy of Dermatology5-fluorouracilcalcipotrieneeruptive squamous atypiasquamous cell carcinoma
Source : Journal of the American Academy of Dermatology
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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