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  • Hair loss drug...

Hair loss drug Spironolactone not tied to recurrence risk in breast cancer patients

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-09-14T18:23:18+05:30  |  Updated On 9 Oct 2023 12:44 PM IST
Hair loss drug Spironolactone not tied to recurrence risk in breast cancer patients
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WASHINGTON - Spironolactone is not associated with increased risk of female breast cancer recurrence, according to research from the George Washington University (GW) Department of Dermatology. The study, published in the Journal of the American Academy of Dermatology, found that the drug may be safe for use in treating breast cancer survivors with female pattern hair loss.

Androgens contribute significantly to the pathogenesis of female patterned hair loss. The current treatment of topically applied minoxidil (also known as Rogaine), thought to increase scalp blood flow and maintain hair growth, is approved by the U.S. Food and Drug Administration. However, antiandrogen drugs, like spironolactone, have also been used to treat female patterned hair loss, but used off-label. Research confirming the safety of this drug for breast cancer survivors is critical for patients considering this treatment option.

"Spironolactone is used for androgenic alopecia because of its ability to halt the progression of hair loss and its long-term safety profile," said Adam Friedman, MD, interim chair and professor in the Department of Dermatology at the GW School of Medicine and Health Sciences, director of the Supportive Oncodermatology Clinic at GW Cancer Center, and the senior author on the study. "However, little is known about its safety in breast cancer survivors, which is of concern considering the drug's estrogenic effects could pose a theoretical risk of breast cancer recurrence."

The multidisciplinary research team, led by first author Chapman Wei, a fourth-year MD student and research fellow in the GW Department of Dermatology, conducted a retrospective analysis of data from the Humana Insurance Database. They identified patients with a history of breast cancer and stratified groups based on spironolactone usage. They then analyzed patient characteristics and cancer recurrence rates between the cohorts.

The breast cancer recurrence rate for the group prescribed spironolactone was not statistically different from the cohort of patients who did not take spironolactone after adjusting for patient characteristics, both of which were well within the range of expected recurrence rates.

"According to our analysis, spironolactone is not independently responsible for increased risk of breast cancer recurrence," Friedman said. "The drug could be used as an additional treatment option for alopecia in female breast cancer patients who are disease-free."

The authors recommend additional prospective studies and clinical trials to further assess the efficacy and safety of spironolactone in patients who have cancer remission to confirm its safety.

https://www.jaad.org/article/S0190-9622(20)30950-6/fulltext


hair lossspironolactonebreast cancerjournal of the american academy of dermatology
Source : Journal of the American Academy of Dermatology
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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