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Hormonal therapy plus laser hair removal significantly improves QOL in PCOS patients: Study
Cairo, Egypt: A combination of hormonal treatment with laser hair removal (LHR) is better than metformin and LHR combo for achieving a significant improvement in QOL in PCOS patients with hirsutism, finds a recent study. The study is published in the Journal of Drugs in Dermatology.
Hirsutism affects about 10% to 20% of females, resulting in significant psychological damage and social embarrassment. Polycystic ovary syndrome (PCOS) is a major cause of hirsutism. Nevine Dorgham, Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt, and colleagues aimed to assess the impact of adding combined oral contraceptives (COCs) or metformin to laser hair removal on the quality of life of PCOS patients with hirsutism.
The study included 150 PCOS patients diagnosed with hirsutism. Patients were randomized to three groups -- group 1 received laser hair removal alone, group 2 received metformin and laser hair removal, and group 3 received COCs and laser hair removal.
A diode laser with a wavelength of 810 nm was used for hair removal in all patients according to a protocol of 6 monthly sessions followed by another two sessions after three and six months. Patients were assessed using a visual analog scale (VAS) and Dermatology Life Quality Index (DLQI) and a customized questionnaire (Hirsutism Life Quality Index; HLQI).
Key findings of the study include:
- All patients showed a significant improvement in both quality indices (DLQI and HLQI) after treatment relative to pretreatment.
- Group 3 showed significantly better improvements when compared with group 2 and group 1.
- At three and six months, group 3 showed non-significantly better DLQI and HLQI as compared with at zero months.
- Group 2 patients displayed significant worsening of both DLQI and HLQI scores at three months, with subsequent improvements again at six.
- Group 1 patients showed nonsignificant worsening at three months, and significant worsening at 6 months.
"Combining hormonal treatment with laser hair removal can achieve greater hair reduction, significant improvements in patients' QOL, and better maintenance as compared with when combining metformin with laser hair removal or conducting alone," wrote the authors.
Reference:
The study titled, "Adding Combined Oral Contraceptives or Metformin to Laser Treatment in Polycystic Ovarian Syndrome Hirsute Patients," is published in the Journal of Drugs in Dermatology.
DOI: https://jddonline.com/articles/dermatology/S1545961621P0302X
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751