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Low Vitamin D levels worsen Hidradenitis suppurativa, Claims Study
Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of the hair follicles in intertriginous areas. The etiology of Hidradenitis suppurativa (HS) is still being elucidated. In a recent study, researchers have found that lower vitamin D levels were associated with worsening of Hidradenitis suppurativa (HS) disease. The research has been published in THE JOURNAL OF DERMATOLOGY on February 24, 2021.
Vitamin D exerts functions in skin physiology by modulating keratinocyte proliferation and different immunoregulatory processes. Vitamin D modifies keratinocyte biology and modulates both innate and adaptive immune responses, making it a reasonable consideration as we search for effective therapies for this difficult disease. Previous studies have demonstrated the association between vitamin D and HS severity. For the same, Dr Chiara Moltrasio and his team conducted a study to confirm the association between Hidradenitis suppurativa and Vitamin D.
It was a retrospective study of 250 patients hospitalized with hidradenitis suppurativa. Researchers initially measured the serum 25-hydroxy-vitamin D (25OHD) levels before starting any specific HS treatment. They used electrochemiluminescence to measure 25OHD and, they also used immunoturbidimetry to determine the CRP levels. . In this study, the researchers determined the vitamin D deficiency as 25OHD levels less than 20 ng/mL and found approximately 80% of patients were classified as vitamin D–deficient.
Key findings of the study were:
- Upon analysis, the researchers observed that the majority of patients had vitamin D deficiency (<20 ng/mL), and 20.16% had vitamin D insufficiency (20–30 ng/mL).
- They found that patients with vitamin D deficiency demonstrated significantly higher mean International HS Severity Score System (IHS4) values (12.59 vs 3.06; P < .0001) and C-reactive protein (CRP) levels (6.75 vs 1.39 mg/L; P < .0001) compared with those with vitamin D insufficiency.
- They also found an inverse correlation between vitamin D level and IHS4 score.
The authors concluded, "our results are consistent with previous studies conducted on low numbers of patients and confirm that HS-Severity and inflammation are associated with major hypovitaminosis D."
They further added, "We suggests that the assessment of Vitamin D levels should be proposed in the initial evaluation of HS patients".
For further information:
https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.15797
Medical Dialogues Bureau consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers. Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751