Needling and MMR effective therapeutic modalities for management of genital warts

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-06-24T09:30:50+05:30 | Updated On 24 Jun 2023 4:22 PM IST

A new study published in the International Journal of Dermatology by Nehal El-Fakkar and team showed that both measles, mumps and rubella (MMR) vaccine and needling are efficient immunotherapeutic methods for treating genital warts.

One of the most typical sexually transmitted illnesses is genital warts brought on by the human papillomavirus (HPV). The long latency, many lesions, high recurrence rate, and propensity for malignant transformation are significant therapeutic problems. Traditional treatment approaches are known to be lesion-focused, but intralesional immunotherapy was developed to act beyond individual lesions and to address the issues from the past by injecting known antigens, such as the measles, mumps, and rubella vaccine, to arouse the immune system against HPV. Another immunotherapeutic method that does not involve injecting antigens is needle-induced autoinoculation. Therefore, this study was conducted in order to examine the effectiveness of needling-induced autoinoculation for treating genital warts.

50 patients were split into two equal groups, each with four or more recurring genital warts. One group received intralesional MMR injections every two weeks for a total of three sessions, whereas the other received needling-induced autoinoculation. Following the final session, follow-up was conducted for 8 weeks.

The key findings of this study were:

1. The therapeutic effects of both needling and MMR were statistically significant.

2. The number of lesions and their size both significantly improved after needling (P = 0.000 and P = 0.003, respectively).

3. Parallel to this, MMR demonstrated a substantial improvement in both the quantity and size (P = 0.001 and P = 0.021, respectively) of lesions.

4. Regarding the quantity (P = 0.860) and size (P = 0.929) of lesions, there was no statistical significant difference between the outcomes of the two treatments.

Reference:

El‐fakkar, N. M. Z., El‐Khateeb, E. A., & Gamal, N. (2023). Evaluation of needling‐induced autoinoculation in the management of genital warts. In International Journal of Dermatology. Wiley. https://doi.org/10.1111/ijd.16723

Measles mumps and rubella vaccineGenital wartsInternational Journal of Dermatologyautoinoculation

Source : International Journal of Dermatology

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751