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Oxybutynin Shows Promising Results in Excessive Sweating
Egypt: New research has suggested that oxybutynin, a medication commonly used to treat urinary incontinence, could be an effective treatment for Hyperhidrosis, according to the study published in Archives of Dermatological Research.
Hyperhidrosis is a condition where excessive sweating occurs in localized areas due to hyperfunctioning sweat glands. The study aimed to investigate patient satisfaction and the effectiveness of oxybutynin in treating Hyperhidrosis.
The study involved a prospective systematic review and meta-analysis of six randomized controlled trials on PROSPERO, with a total of 293 patients. A total of 3 electronic databases were researched namely- PubMed, Scopus and Web of Science. The studies included compared patients who were assigned to receive either oxybutynin or a placebo. The researchers assessed the risk of bias using the Cochrane risk of bias assessment tool (ROB2).
The studies revealed the following clinical findings:
- The results showed that oxybutynin significantly improved hyperhidrosis severity, as measured by the Hyperhidrosis Disease Severity Scale (HDSS) improvement.
- Oxybutynin also improved the quality of life of patients with hyperhidrosis.
- There was no significant difference between oxybutynin and placebo in terms of dry mouth, a common side effect of the medication.
The researchers concluded that oxybutynin could be a significant treatment option for hyperhidrosis and should be highlighted to clinicians. However, they also noted that more clinical trials are needed to fully understand the optimum benefit of the medication.
“Hyperhidrosis is a common condition that can have a significant impact on patient’s quality of life. Current treatment options include antiperspirants, iontophoresis, and botulinum toxin injections. The discovery of oxybutynin as a potential treatment option could offer new hope to patients with hyperhidrosis.” added Dr. Mohamed El-Samahy the lead author of the study.
Reference:
El-Samahy, M., Mouffokes, A., Badawy, M.M. et al. Safety and efficacy of oxybutynin in patients with hyperhidrosis: systematic review and meta-analysis of randomized controlled trials. Arch Dermatol Res (2023). https://doi.org/10.1007/s00403-023-02587-5
Dr. Mahalakshmi Sivashankaran joined Medical Dialogues as an Intern in 2023. She is a BDS graduate from Manipal College of Dental Sciences, Mangalore Batch 2022, and worked as a Junior Resident at VMMC & Safdarjung Hospital at the Department of Dental Surgery till January 2023. She has completed a Diploma in Executive Healthcare management from the Loyola Institute of Business Administration, developing skills in Healthcare Management and Administration. She covers several medical specialties including Dental, ENT, Diagnostics, Pharmacology, Neurology, and Cardiology.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751