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  • PEST and BMI...

PEST and BMI predictive factors for Development of Psoriatic arthritis in Psoriasis

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-09T20:00:22+05:30  |  Updated On 9 Sept 2022 8:00 PM IST
PEST and BMI predictive factors for Development of Psoriatic arthritis in Psoriasis
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Psoriasis Epidemiology Screening Tool (PEST) and body mass index (BMI) are the important factors in predicting the development of Psoriatic Arthritis in patients with Psoriasis for over 2 years as per new research that was published in the 'Journal of the American Academy of Dermatology.'

Psoriasis can affect an individual in a variety of ways. It includes cutaneous and psoriatic arthritis. Persons with psoriasis can develop psoriatic arthritis at any time, causing severe disability. Hence to identify the characteristics that predict psoriatic arthritis (PsA) onset among patients with psoriasis (PsO) researchers from the U.S.A conducted a study model which helps to predict the 2-year risk of development of psoriatic arthritis in psoriatic patients aiding in the early diagnosis and management.

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A prospective cohort of patients from the CorEvitas Psoriasis Registry participated in the study. Patients without PsA at enrollment were taken and were followed up for 24 months. Unregularized and regularized logistic regression models were developed and tested using descriptive variables to predict dermatologist-identified PsA at 24 months. Model performance was compared using the area under the receiver-operating-characteristic curve (AUC), sensitivity, and specificity.

Key findings:

  • A total of 1489 patients were included.
  • Nine unique predictive models were developed and tested.
  • The optimal model, including Psoriasis Epidemiology Screening Tool (PEST), body mass index (BMI), modified Rheumatic Disease Comorbidity Index, work status, alcohol use, and patient-reported fatigue predicted onset of PsA within 24 months.
  • A parsimonious model including PEST and BMI had similar performance.
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Despite the limitations in the study like the PsA misclassification bias by dermatologists, researchers concluded from the study that PEST and BMI were important factors in predicting the development of PsA in patients with PsO over 2 years. This study model could be foundational for future PsA risk model development.

For further reading, click here: https://doi.org/10.1016/j.jaad.2022.07.060

Ogdie A, Harrison RW, McLean RR, et al. Prospective Cohort Study of Psoriatic Arthritis Risk in Patients With Psoriasis in a Real-World Psoriasis Registry [published online ahead of print, 2022 Aug 17]. J Am Acad Dermatol. 2022; S0190-9622(22)02543-9.

Psoriasis Epidemiology Screening Tool (PEST)body mass index (BMI)psoriasis (PsO)psoriatic arthritis (PsA)PsA risk model development
Source : Journal of the American Academy of Dermatology
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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