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  • selumetinib effective,...

selumetinib effective, safe in kids with symptomatic and inoperable plexiform neurofibromas

Dr. Shravani DaliWritten by Dr. Shravani Dali Published On 2022-04-09T10:00:13+05:30  |  Updated On 9 April 2022 9:36 AM GMT
selumetinib effective, safe in kids with symptomatic and inoperable plexiform neurofibromas
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Selumetinib is effective and safe in children with symptomatic and inoperable plexiform neurofibromas (PN), according to a recent study published in Neurology.

Although the recent approval of selumetinib is expected to transform the management of children with neurofibromatosis type 1 (NF1), particularly those with symptomatic and inoperable plexiform neurofibromas, no systematic review has summarized its efficacy and safety based on the latest studies. This study was conducted to systematically evaluate the efficacy and safety of selumetinib in children with NF1.

Original articles reporting the efficacy and safety of selumetinib in patients with NF1 were identified in PubMed and EMBASE up to January 28, 2021. The pooled objective response rates (ORRs) and disease control rates (DCRs) were calculated using the DerSimonian–Laird method based on random-effects modelling. The pooled proportion of adverse events (AEs) was also calculated. The quality of the evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation system.

Results of the study are:

Five studies involving 126 patients were included in our analysis. The studies had a very low to moderate quality of the evidence. The pooled ORR was 73.8% (95% CI 57.3%–85.5%) and the DCR was 92.5% (95% CI 66.5%–98.7%). The 2 most common AEs were diarrhoea, which had a pooled rate of 63.8% (95% CI 52.9%–73.4%), and an increase in creatine kinase levels, which had a pooled rate of 63.3% (95% CI 35.6%–84.3%).

Their results indicate that selumetinib is an effective and safe treatment for pediatric patients with symptomatic, inoperable plexiform neurofibromas. Further larger-scale randomized controlled studies are needed to confirm the long-term outcome of patients treated with this drug.

Reference:

Efficacy and Safety of Selumetinib in Pediatric Patients With Neurofibromatosis Type 1: A Systematic Review and Meta-analysis by Jisun Hwang, et al. published in the Neurology.


neurologyEfficacySafetySelumetinibPediatric PatientsNeurofibromatosis Type 1
Source : Neurology
Dr. Shravani Dali
Dr. Shravani Dali

    BDS

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

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