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  • Skin microbiota linked...

Skin microbiota linked to development of hypopigmentation in Lichen striatus

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-02-01T01:30:22+05:30  |  Updated On 2 Feb 2024 5:56 PM IST
Skin microbiota linked to development of hypopigmentation in Lichen striatus
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In a ground-breaking study, researchers have delved into the intricate world of Lichen Striatus (LS) an acquired skin disorder that often manifests in childhood. They found that skin microbiota may play a potential role in the development of hypopigmentation and a treatment target to reduce the duration of LS and alleviate hypopigmentation.

The study results were published in the Journal of the European Academy of Dermatology & Venereology.

Also Read: Oral Acitretin and TAC Effective in treatment of Oral Lichen Planus: JAMA

LS is characterized by a distinct linear pattern along Blaschko's lines, and while the lesions typically regress within months, up to 50% of cases exhibit a lingering issue—hypopigmentation. Unlike many other inflammatory skin conditions, LS shows an unusually high incidence of hypopigmentation, leaving scientists puzzled about the root cause. Hence, researchers conducted a study with the primary objective of unraveling the mysteries surrounding LS-associated hypopigmentation by scrutinizing the differences in the skin microbiome between LS patients with and without this specific manifestation.

Employing cutting-edge techniques the researchers utilized whole genome sequencing of skin biopsies and conducted meticulous bioinformatics analyses.

Findings:

  • The results were nothing short of revelatory.
  • Certain microbes, notably Cutibacterium acnes, commonly associated with hypopigmented skin disorders, were more abundant in patients with LS exhibiting hypopigmentation than in those without this characteristic.

    This discovery brings a new dimension to our understanding of LS and its intricate relationship with hypopigmentation. While the exact mechanisms linking these microbes to hypopigmentation remain to be fully elucidated, the study opens up promising avenues for future research and potential therapeutic interventions.

    Also Read: Metronidazole reasonable treatment option for patients with symptomatic oral lichen planus

    The implications of these findings are far-reaching. The skin microbiota, it appears, may play a pivotal role in the development of hypopigmentation in LS. This insight not only sheds light on the underlying mechanisms of LS but also presents a compelling case for considering the skin microbiome as a viable treatment target. If the microbial composition in the skin can be modulated or targeted, it could pave the way for innovative treatments to reduce both the duration of LS and the associated hypopigmentation.
    Further reading: Yu Y, Lee B, Shin K, et al. Association between the skin microbiome and lichen striatus hypopigmentation: Cutibacterium acnes as a potential cause. J Eur Acad Dermatol Venereol. Published online January 3, 2024. doi:10.1111/jdv.19746

    Journal of the European Academy of Dermatology and VenerologyJEADVYeuni Yulichen striatusCutibacterium acnesDermatology
    Source : Journal of the European Academy of Dermatology & Venereology
    Dr.Niharika Harsha B
    Dr.Niharika Harsha B

      BDS, MDS

      Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

      Dr. Kamal Kant Kohli
      Dr. Kamal Kant Kohli

      Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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